| Literature DB >> 17950497 |
Emilia D Naydenova1, Petar T Todorov, Margarita N Topashka-Ancheva, Georgi Ts Momekov, Tsvetelina Z Yordanova, Spiro M Konstantinov, Kolio D Troev.
Abstract
A series of Calpha,alpha-disubstituted cyclic derivatives of N-(phosphonomethyl) glycine have been synthesized and characterized. They exhibited moderate clastogenicity, low antiproliferative activity on mice bone marrow cells and well expressed cytotoxicity against human tumor cell lines. The 8- and 12-membered cyclic analogs proved superior to the remaining compounds and were found to trigger apoptotic cell death in DOHH-2 cells. The latter compound caused 50% inhibition of the viability of hemobastose-derived cell lines at concentrations ranging from 20 to 67 microM.Entities:
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Year: 2007 PMID： 17950497 DOI： 10.1016/j.ejmech.2007.08.010
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514