Literature DB >> 17950471

Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine.

Asim J Rashid1, Brian F O'Dowd, Vaneeta Verma, Susan R George.   

Abstract

There is strong evidence for the existence of Gq/11-coupled dopamine receptors in the brain but the mechanism by which dopamine signaling activates Gq/11, or its roles in neuronal function, are only just beginning to be understood. The importance of such a pathway is underlined by putative links between dopamine-regulated phosphoinositide signaling and several central nervous system disorders that include schizophrenia, addiction and Parkinson's disease.

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Year:  2007        PMID： 17950471     DOI： 10.1016/j.tips.2007.10.001

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  38 in total

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Review 3.  Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance.

Authors:  Melissa L Perreault; Ahmed Hasbi; Brian F O'Dowd; Susan R George
Journal:  Neuropsychopharmacology       Date:  2013-06-18       Impact factor: 7.853

Review 4.  Moonlighting proteins and protein-protein interactions as neurotherapeutic targets in the G protein-coupled receptor field.

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Journal:  Neuropsychopharmacology       Date:  2013-09-06       Impact factor: 7.853

Review 5.  Dopamine receptors - IUPHAR Review 13.

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6.  A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism.

Authors:  Ahmed Hasbi; Melissa L Perreault; Maurice Y F Shen; Lucia Zhang; Ryan To; Theresa Fan; Tuan Nguyen; Xiaodong Ji; Brian F O'Dowd; Susan R George
Journal:  FASEB J       Date:  2014-07-25       Impact factor: 5.191

Review 7.  G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.

Authors:  Sergi Ferré; Vicent Casadó; Lakshmi A Devi; Marta Filizola; Ralf Jockers; Martin J Lohse; Graeme Milligan; Jean-Philippe Pin; Xavier Guitart
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Authors:  Sang-Min Lee; Andrew Kant; Daniel Blake; Vishakantha Murthy; Kevin Boyd; Steven J Wyrick; Richard B Mailman
Journal:  Neuropharmacology       Date:  2014-06-12       Impact factor: 5.250

9.  Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex.

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Journal:  J Neurosci       Date:  2009-12-09       Impact factor: 6.167

10.  Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth.

Authors:  Ahmed Hasbi; Theresa Fan; Mohammad Alijaniaram; Tuan Nguyen; Melissa L Perreault; Brian F O'Dowd; Susan R George
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-30       Impact factor: 11.205
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