| Literature DB >> 17950289 |
R Chakrabarti1, J M Walker, E G Chapman, S P Shepardson, R J Trdan, J P Curole, G T Watters, D T Stewart, S Vijayaraghavan, W R Hoeh.
Abstract
Our previous study documented expression of a male-transmitted cytochrome c oxidase subunit II protein (MCOX2), with a C-terminus extension (MCOX2e), in unionoidean bivalve testes and sperm mitochondria. Here, we present evidence demonstrating that MCOX2 is seasonally expressed in testis, with a peak shortly before fertilization that is independent of sperm density. MCOX2 is localized to the inner and outer sperm mitochondrial membranes and the MCOX2 antibody's epitope is conserved across >65 million years of evolution. We also demonstrate the presence of male-transmitted mtDNA and season-specific MCOX2 spatial variation in ovaries. We hypothesize that MCOX2 plays a role in reproduction through gamete maturation, fertilization and/or embryogenesis.Entities:
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Year: 2007 PMID： 17950289 PMCID： PMC2141648 DOI： 10.1016/j.febslet.2007.10.006
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124