Literature DB >> 17949408

Intentional pathogen killing--or denial of substrate?

J Cunliffe1.   

Abstract

For years, the accepted view in immunology has been that a core function of the immune system is to identify and eliminate invading micro-organisms (generally referred to as 'pathogens'). Metaphorically, the system locates, chases, attacks, kills, disposes of and eliminates 'pathogens'. This is encapsulated in the phrase 'intentional pathogen killing'. This purpose has remained, more or less, unchallenged until the 1990s but its authority is now becoming suspect. In a series of published articles, I have suggested that the core function of the immune (or morphostatic) system is to dispose of tissue debris (mess/non-mess discrimination) and restore order. The debris of degenerating cells provides a rich source of nutrients for micro-organisms. Could it be that the major goal of the immune system is to rapidly dispose of such debris? This strategy could lead to a 'denial-of-nutrient-substrate' that starves invading bacteria out of contention and, in consequence, suppresses infection. This perspective can be adapted to encompass the patho-physiology of other infective organisms. While this perspective sits well with the morphostasis model, it could also be applied to other models.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17949408     DOI: 10.1111/j.1365-3083.2007.02017.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN: 0300-9475            Impact factor:   3.487


  4 in total

Review 1.  What roles do regulatory T cells play in the control of the adaptive immune response?

Authors:  Melvin Cohn
Journal:  Int Immunol       Date:  2008-07-25       Impact factor: 4.823

2.  A rationalized set of default postulates that permit a coherent description of the immune system amenable to computer modeling.

Authors:  M Cohn
Journal:  Scand J Immunol       Date:  2008-10       Impact factor: 3.487

3.  Ventilator-Associated Pneumonia, Multidrug-Resistant Bacteremia and Infection Control Interventions in an Intensive Care Unit: Analysis of Six-Year Time-Series Data.

Authors:  Amalia Papanikolopoulou; Helena C Maltezou; Athina Stoupis; Anastasia Pangalis; Christos Kouroumpetsis; Genovefa Chronopoulou; Yannis Kalofissoudis; Evangelos Kostares; Fotini Boufidou; Maria Karalexi; Vasiliki Koumaki; Nikos Pantazis; Athanasios Tsakris; Maria Kantzanou
Journal:  Antibiotics (Basel)       Date:  2022-08-19

Review 4.  How do regulatory T cells work?

Authors:  A Corthay
Journal:  Scand J Immunol       Date:  2009-10       Impact factor: 3.487

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.