Literature DB >> 17947589

Thymosin beta 4 induces hair growth via stem cell migration and differentiation.

Deborah Philp1, Sharleen St-Surin, Hee-Jae Cha, Hye-Sung Moon, Hynda K Kleinman, Michael Elkin.   

Abstract

Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.

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Year:  2007        PMID： 17947589     DOI： 10.1196/annals.1415.009

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  22 in total

1.  Treatment of traumatic brain injury with thymosin β₄ in rats.

Authors:  Ye Xiong; Asim Mahmood; Yuling Meng; Yanlu Zhang; Zheng Gang Zhang; Daniel C Morris; Michael Chopp
Journal:  J Neurosurg       Date:  2010-05-21       Impact factor: 5.115

2.  Expression patterns of Thymosin β4 and cancer stem cell marker CD133 in ovarian cancers.

Authors:  Yong-Il Ji; Bo-Young Lee; Yun-Jeong Kang; Jin-Ok Jo; Sang Ho Lee; Heung Yeol Kim; Young-Ok Kim; Chulmin Lee; Suk Bong Koh; Ari Kim; Ji Young Lee; Min Hyung Jung; Mee Sun Ock; Hee-Jae Cha
Journal:  Pathol Oncol Res       Date:  2012-10-10       Impact factor: 3.201

3.  Tβ4-overexpression based on the piggyBac transposon system in cashmere goats alters hair fiber characteristics.

Authors:  Bingbo Shi; Qiang Ding; Xiaolin He; Haijing Zhu; Yiyuan Niu; Bei Cai; Jiao Cai; Anming Lei; Danju Kang; Hailong Yan; Baohua Ma; Xiaolong Wang; Lei Qu; Yulin Chen
Journal:  Transgenic Res       Date:  2016-11-29       Impact factor: 2.788

4.  Elevated expression of thymosin β4, vascular endothelial growth factor (VEGF), and hypoxia inducible factor (HIF)-1α in early-stage cervical cancers.

Authors:  Nam Soo Kim; Yun-Jeong Kang; Jin-Ok Jo; Heung Yeol Kim; Young Rim Oh; Young-Ok Kim; Min Hyung Jung; Mee Sun Ock; Hee-Jae Cha
Journal:  Pathol Oncol Res       Date:  2011-01-07       Impact factor: 3.201

5.  Association between serum thymosin β4 levels of rheumatoid arthritis patients and disease activity and response to therapy.

Authors:  Ran Song; Hyun Mi Choi; Hyung-In Yang; Myung Chul Yoo; Yong-Beom Park; Kyoung Soo Kim
Journal:  Clin Rheumatol       Date:  2012-06-01       Impact factor: 2.980

6.  Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury in rats.

Authors:  Ye Xiong; Yanlu Zhang; Asim Mahmood; Yuling Meng; Zheng Gang Zhang; Daniel C Morris; Michael Chopp
Journal:  J Neurosurg       Date:  2012-02-10       Impact factor: 5.115

7.  Exogenous thymosin beta4 prevents apoptosis in human intervertebral annulus cells in vitro.

Authors:  H Tapp; R Deepe; J A Ingram; E G Yarmola; M R Bubb; E N Hanley; H E Gruber
Journal:  Biotech Histochem       Date:  2009-12       Impact factor: 1.718

8.  Thymosin β4 impeded murine stem cell proliferation with an intact cardiovascular differentiation.

Authors:  Li Nie; Shi-Jun Gao; Ya-Nan Zhao; Jacob Masika; Hong-Yan Luo; Xin-Wu Hu; Liang-Pin Zhang; Ying Zeng; Jürgen Hescheler; Hua-Min Liang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2016-07-05

Review 9.  Potential role of thymosin Beta 4 in liver fibrosis.

Authors:  Jieun Kim; Youngmi Jung
Journal:  Int J Mol Sci       Date:  2015-05-08       Impact factor: 5.923

10.  Thymosin Beta-4 Induces Mouse Hair Growth.

Authors:  Xiaoyu Gao; Hao Liang; Fang Hou; Zhipeng Zhang; Mingtu Nuo; Xudong Guo; Dongjun Liu
Journal:  PLoS One       Date:  2015-06-17       Impact factor: 3.240
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