BACKGROUND: Recent cases of infants with bullous pemphigoid (BP) prompted us to explore the clinical and laboratory features of childhood BP. OBJECTIVES: We sought to explore the characteristics of infantile BP and compare them with childhood BP. METHODS: All new consecutive cases of infantile BP referred to dermatologic departments in Israel during 2004 to 2006 were retrospectively reviewed. All reported cases in the English- and foreign-language medical literature were gathered and statistical analysis of all cases was performed. RESULTS: Reports on infantile BP are rapidly increasing. Among 78 reported children with BP, 42 (53%) occurred in the first year of life. The incidence of infantile BP in Israel in the last years is 2.36:100,000/y. Predisposition for acral involvement is significantly higher in infantile BP than in childhood BP (79% vs 17%, P < .001), whereas genital involvement is very rare (5% vs 44%, P = .002). Laboratory parameters were not significantly different, except for a more frequent IgM deposition at the dermoepidermal junction in childhood BP (29% vs 10%, P = .042). LIMITATIONS: Statistical analyses of published cases may not be representative and could be affected by possible reporting biases. CONCLUSIONS: Infantile BP may not be as rare as commonly stated. Age-related differences in regional distribution of lesions in BP were demonstrated. No major differences regarding laboratory results, treatment, and prognosis were found.
BACKGROUND: Recent cases of infants with bullous pemphigoid (BP) prompted us to explore the clinical and laboratory features of childhood BP. OBJECTIVES: We sought to explore the characteristics of infantile BP and compare them with childhood BP. METHODS: All new consecutive cases of infantile BP referred to dermatologic departments in Israel during 2004 to 2006 were retrospectively reviewed. All reported cases in the English- and foreign-language medical literature were gathered and statistical analysis of all cases was performed. RESULTS: Reports on infantile BP are rapidly increasing. Among 78 reported children with BP, 42 (53%) occurred in the first year of life. The incidence of infantile BP in Israel in the last years is 2.36:100,000/y. Predisposition for acral involvement is significantly higher in infantile BP than in childhood BP (79% vs 17%, P < .001), whereas genital involvement is very rare (5% vs 44%, P = .002). Laboratory parameters were not significantly different, except for a more frequent IgM deposition at the dermoepidermal junction in childhood BP (29% vs 10%, P = .042). LIMITATIONS: Statistical analyses of published cases may not be representative and could be affected by possible reporting biases. CONCLUSIONS: Infantile BP may not be as rare as commonly stated. Age-related differences in regional distribution of lesions in BP were demonstrated. No major differences regarding laboratory results, treatment, and prognosis were found.
Authors: Eugenio Galdino de Mendonça Reis-Filho; Tainah de Almeida Silva; Luiza Helena de Lima Aguirre; Carmelia Matos Santiago Reis Journal: An Bras Dermatol Date: 2013 Nov-Dec Impact factor: 1.896
Authors: Alice Y Chan; Divya Punwani; Theresa A Kadlecek; Morton J Cowan; Jean L Olson; Erin F Mathes; Uma Sunderam; Shu Man Fu; Rajgopal Srinivasan; John Kuriyan; Steven E Brenner; Arthur Weiss; Jennifer M Puck Journal: J Exp Med Date: 2016-01-18 Impact factor: 14.307