OBJECTIVE: To evaluate changes in the molecular epidemiology of tuberculosis (TB) in Zaragoza, Spain, over a decade that has seen large social and health changes, including the attenuation of the human immunodeficiency virus (HIV) epidemic and increased immigration. DESIGN: A population-based molecular study was conducted using standard restriction fragment length polymorphism IS6110 typing that included all patients with bacteriologically confirmed TB living in the Zaragoza area from 2001 to 2004. The current situation was compared with that described in a previous study from 1993 to 1995. RESULTS: A total of 454 Mycobacterium tuberculosis isolates were genotyped; 239 (52.6%) were grouped in 45 clusters composed of 2 to 85 isolates. Independent risk factors for clustering were identified. The main differences with the previous study were the increase of TB cases among immigrants, a decrease in HIV-TB co-infected patients and the occurrence of a large TB outbreak involving 85 patients (M. tuberculosis Zaragoza [MTZ] strain). CONCLUSION: A change in the epidemiological pattern of TB has been observed in the last years. TB transmission is more common among the Spanish-born population, while foreign birth is significantly less associated with clustering. A single epidemic strain caused 18.7% of all TB cases.
OBJECTIVE: To evaluate changes in the molecular epidemiology of tuberculosis (TB) in Zaragoza, Spain, over a decade that has seen large social and health changes, including the attenuation of the human immunodeficiency virus (HIV) epidemic and increased immigration. DESIGN: A population-based molecular study was conducted using standard restriction fragment length polymorphism IS6110 typing that included all patients with bacteriologically confirmed TB living in the Zaragoza area from 2001 to 2004. The current situation was compared with that described in a previous study from 1993 to 1995. RESULTS: A total of 454 Mycobacterium tuberculosis isolates were genotyped; 239 (52.6%) were grouped in 45 clusters composed of 2 to 85 isolates. Independent risk factors for clustering were identified. The main differences with the previous study were the increase of TB cases among immigrants, a decrease in HIV-TB co-infectedpatients and the occurrence of a large TB outbreak involving 85 patients (M. tuberculosis Zaragoza [MTZ] strain). CONCLUSION: A change in the epidemiological pattern of TB has been observed in the last years. TB transmission is more common among the Spanish-born population, while foreign birth is significantly less associated with clustering. A single epidemic strain caused 18.7% of all TB cases.
Authors: María Isabel Millán-Lou; Isabel Otal; María Luisa Monforte; María Asunción Vitoria; María José Revillo; Carlos Martín; Sofía Samper Journal: J Clin Microbiol Date: 2015-05-06 Impact factor: 5.948
Authors: M Hanekom; G D van der Spuy; N C Gey van Pittius; C R E McEvoy; K G P Hoek; S L Ndabambi; A M Jordaan; T C Victor; P D van Helden; R M Warren Journal: J Clin Microbiol Date: 2008-08-20 Impact factor: 5.948
Authors: Cari van Schalkwyk; Madeleine Cule; Alex Welte; Paul van Helden; Gian van der Spuy; Pieter Uys Journal: PLoS One Date: 2012-03-29 Impact factor: 3.240
Authors: Ana Isabel López-Calleja; Patricia Gavín; Ma Antonia Lezcano; Ma Asunción Vitoria; Ma José Iglesias; Joaquín Guimbao; Ma Angeles Lázaro; Nalin Rastogi; Ma José Revillo; Carlos Martín; Sofia Samper Journal: BMC Pulm Med Date: 2009-01-14 Impact factor: 3.317
Authors: Inmaculada C Pérez Del Molino Bernal; Troels Lillebaek; Mathias K Pedersen; Luis Martinez-Martinez; Dorte B Folkvardsen; Jesús Agüero; E Michael Rasmussen Journal: PLoS One Date: 2016-06-17 Impact factor: 3.240