Literature DB >> 1794450

Effect of tumour-promoting phorbol ester on calcium homeostasis in human platelets.

M Lucas1, F Solano.   

Abstract

The more interesting features of the effects or PMA on [Ca2+]i and ATP release were the following: 1. preincubation with PMA inhibited thrombin-evoked calcium transients; 2. PMA stimulated slightly the release of calcium and ATP whereas inhibited calcium and ATP pools sensitive to thrombin; 3. A23187 reversed the inhibitory effect of PMA; 4. subsaturating thrombin concentrations gave results similar to PMA on thrombin-induced calcium and ATP release but not on [Ca2+]i.

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Year:  1991        PMID: 1794450     DOI: 10.1016/0020-711x(91)90226-d

Source DB:  PubMed          Journal:  Int J Biochem        ISSN: 0020-711X


  1 in total

1.  Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects.

Authors:  Constance C F M J Baaten; Frauke Swieringa; Tomasz Misztal; Tom G Mastenbroek; Marion A H Feijge; Paul E Bock; Marjo M P C Donners; Peter W Collins; Renhao Li; Paola E J van der Meijden; Johan W M Heemskerk
Journal:  Blood Adv       Date:  2018-09-25
  1 in total

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