Literature DB >> 1794446

Leishmania infantum: polyamine biosynthesis and levels during the growth of promastigotes.

R Balaña-Fouce1, M I Escribano, J M Alunda.   

Abstract

1. Decarboxylation of polyamine precursors: L-ornithine and L-methionine was determined along the growth curve of Leishmania infantum promastigotes in vivo, reaching maximum values on day 2 post-inoculum (mid-logarithmic phase). 2. Maximum values of L-ornithine and L-methionine decarboxylation were: 1.97 +/- 0.28 nmol CO2/hr/10(7) promastigotes and 3.18 +/- 0.34 nmol CO2/hr/10(7) promastigotes, respectively. 3. Total (free + conjugated) polyamine content was closely related with the proliferative stage of Leishmania infantum promastigotes. 4. D,L-alpha-difluoromethylornithine (DFMO) and Berenil depleted putrescine levels in a concentration-dependent manner. 5. Total and free putrescine/spermidine ratio varied significantly with the proliferative stage. Minimum values were found in late logarithmic phase (day 3 post-inoculum). 6. Small but detectable amounts of free spermine were detectable along the growth curve of Leishmania infantum promastigotes.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1794446     DOI： 10.1016/0020-711x(91)90218-c

Source DB:  PubMed          Journal:  Int J Biochem        ISSN： 0020-711X


  9 in total

1.  Polyamine N-acetyltransferase in Leishmania amazonensis.

Authors:  M Rojas-Chaves; C Hellmund; R D Walter
Journal:  Parasitol Res       Date:  1996       Impact factor: 2.289

2.  Polyamine content and drug sensitivities of different clonal lines of Leishmania infantum promastigotes.

Authors:  L Carrera; R Balaña-Fouce; J M Alunda
Journal:  Parasitol Res       Date:  1994       Impact factor: 2.289

3.  Putrescine uptake regulation in response to alpha-difluoromethylornithine treatment in Leishmania infantum promastigotes.

Authors:  R Balaña Fouce; M I Escribano; J M Alunda
Journal:  Mol Cell Biochem       Date:  1991-10-16       Impact factor: 3.396

4.  Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice.

Authors:  Rosa M Reguera; Rafael Balaña-Fouce; Melissa Showalter; Suzanne Hickerson; Stephen M Beverley
Journal:  Mol Biochem Parasitol       Date:  2009-01-20       Impact factor: 1.759

5.  Investigation of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-chromen-2-one as a promising coumarin compound for the development of a new and orally effective antileishmanial agent.

Authors:  Eduardo de Figueiredo Peloso; Rafaella Junqueira Merli; Patrícia Ferreira Espuri; Juliana Barbosa Nunes; Fábio Antônio Colombo; Elkin José Torres Sierra; Daniela Carvalho de Paulo; Marcelo Henrique Dos Santos; Diogo Teixeira Carvalho; Marcos José Marques
Journal:  Mol Biol Rep       Date:  2020-10-06       Impact factor: 2.316

6.  Biochemical, mutational and in silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica.

Authors:  Satya Tapas; Pravindra Kumar; Rentala Madhubala; Shailly Tomar
Journal:  PLoS Negl Trop Dis       Date:  2012-02-28

7.  l-Arginine Uptake by Cationic Amino Acid Transporter Promotes Intra-Macrophage Survival of Leishmania donovani by Enhancing Arginase-Mediated Polyamine Synthesis.

Authors:  Abhishek Mandal; Sushmita Das; Ajay Kumar; Saptarshi Roy; Sudha Verma; Ayan Kumar Ghosh; Ruby Singh; Kumar Abhishek; Savita Saini; Abul Hasan Sardar; Bidyut Purkait; Ashish Kumar; Chitra Mandal; Pradeep Das
Journal:  Front Immunol       Date:  2017-07-26       Impact factor: 7.561

8.  Deprivation of L-Arginine Induces Oxidative Stress Mediated Apoptosis in Leishmania donovani Promastigotes: Contribution of the Polyamine Pathway.

Authors:  Abhishek Mandal; Sushmita Das; Saptarshi Roy; Ayan Kumar Ghosh; Abul Hasan Sardar; Sudha Verma; Savita Saini; Ruby Singh; Kumar Abhishek; Ajay Kumar; Chitra Mandal; Pradeep Das
Journal:  PLoS Negl Trop Dis       Date:  2016-01-25

9.  Genetic Manipulation of Leishmania donovani to Explore the Involvement of Argininosuccinate Synthase in Oxidative Stress Management.

Authors:  Abul Hasan Sardar; Armando Jardim; Ayan Kumar Ghosh; Abhishek Mandal; Sushmita Das; Savita Saini; Kumar Abhishek; Ruby Singh; Sudha Verma; Ajay Kumar; Pradeep Das
Journal:  PLoS Negl Trop Dis       Date:  2016-03-03
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.