Literature DB >> 17943658

The use of toxicokinetic data in preclinical safety assessment: a toxicologic pathologist perspective.

Jan-Peter H T M Ploemen1, Hester Kramer, Ernö I Krajnc, Iain Martin.   

Abstract

Collection of toxicokinetic data has become a routine practice during the last 15 years in most general toxicity studies on pharma. It enables the correlation of pathological changes with the plasma concentration of drugs and/or their metabolites. This overview summarizes the use of the toxicokinetic data from the perspective of the toxicologic pathologist.

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Year:  2007        PMID: 17943658     DOI: 10.1080/01926230701584247

Source DB:  PubMed          Journal:  Toxicol Pathol        ISSN: 0192-6233            Impact factor:   1.902


  2 in total

1.  The impact of composite AUC estimates on the prediction of systemic exposure in toxicology experiments.

Authors:  Tarjinder Sahota; Meindert Danhof; Oscar Della Pasqua
Journal:  J Pharmacokinet Pharmacodyn       Date:  2015-04-14       Impact factor: 2.745

2.  Simultaneous Determination of Three Furanocoumarins by UPLC/MS/MS: Application to Pharmacokinetic Study of Angelica dahurica Radix after Oral Administration to Normal and Experimental Colitis-Induced Rats.

Authors:  Youn-Hwan Hwang; Hye Jin Yang; Jin Yeul Ma
Journal:  Molecules       Date:  2017-03-07       Impact factor: 4.411

  2 in total

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