Literature DB >> 17943324

Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura.

Keith K Lau1, Robert J Wyatt, Zina Moldoveanu, Milan Tomana, Bruce A Julian, Ronald J Hogg, Jeannette Y Lee, Wen-Qiang Huang, Jiri Mestecky, Jan Novak.   

Abstract

IgA nephropathy and Henoch-Schönlein purpura nephritis (HSPN) are related diseases characterized by deposits of IgA1-containing immune complexes in the renal mesangium. Adult patients with IgA nephropathy have aberrantly glycosylated IgA1 (galactose-deficient O-linked glycans) in the circulation and renal deposits. However, IgA1 glycosylation has not been studied in pediatric patients with IgA nephropathy. Using our quantitative lectin enzyme-linked immunosorbent assay (ELISA) test, we measured serum levels of galactose-deficient IgA1 of children with IgA nephropathy and HSPN and controls. Children with IgA nephropathy and HSPN had serum levels higher than those of healthy children or renal-disease controls with C1q nephropathy. Furthermore, lectin ELISA identified patients with HSPN whose clinical course mimicked that of IgA nephropathy. In summary, pediatric patients with IgA nephropathy and HSPN have an aberrancy in the glycosylation in IgA1 O-linked glycans that is similar to that in adults with IgA nephropathy.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17943324     DOI： 10.1007/s00467-007-0623-y

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  28 in total

Review 1.  Pediatric IgA nephropathies: clinical aspects and therapeutic approaches.

Authors:  Noel M Delos Santos; Robert J Wyatt
Journal:  Semin Nephrol       Date:  2004-05       Impact factor: 5.299

2.  Purpura followed by proteinuria in a 7-year-old girl.

Authors:  Keith K Lau; Robert J Wyatt; Lillian W Gaber
Journal:  Am J Kidney Dis       Date:  2005-12       Impact factor: 8.860

3.  Repeat renal biopsy in children with IgA nephropathy.

Authors:  N Yoshikawa; K Iijima; S Matsuyama; J Suzuki; A Kameda; S Okada; H Nakamura
Journal:  Clin Nephrol       Date:  1990-04       Impact factor: 0.975

4.  Impairment of jacalin binding to serum IgA in IgA nephropathy.

Authors:  P M Andre; P Le Pogamp; D Chevet
Journal:  J Clin Lab Anal       Date:  1990       Impact factor: 2.352

5.  Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy.

Authors:  J Mestecky; M Tomana; P A Crowley-Nowick; Z Moldoveanu; B A Julian; S Jackson
Journal:  Contrib Nephrol       Date:  1993       Impact factor: 1.580

6.  Glycosylation of circulating IgA in patients with IgA nephropathy modulates proliferation and apoptosis of mesangial cells.

Authors:  Alessandro Amore; Paola Cirina; Giovanni Conti; Paola Brusa; Licia Peruzzi; Rosanna Coppo
Journal:  J Am Soc Nephrol       Date:  2001-09       Impact factor: 10.121

7.  Angiotensin-converting enzyme genotype and outcome in pediatric IgA nephropathy.

Authors:  Noel M Delos Santos; Bettina H Ault; Ali G Gharavi; Stephen B Kritchevsky; Michael W Quasney; Elizabeth C Jackson; Kimberly A Fisher; Susan Y Woodford; Bonnie L Mitchell; Lillian W Gaber; Kristopher L Arheart; Robert J Wyatt
Journal:  Pediatr Nephrol       Date:  2002-06-18       Impact factor: 3.714

8.  Primary IgA glomerulonephritis and Schönlein-Henoch purpura nephritis: Clinicopathological and immunohistological characteristics.

Authors:  Y Nakamoto; Y Asano; K Dohi; M Fujioka; H Iida; H Kida; Y Kibe; N Hattori; J Takeuchi
Journal:  Q J Med       Date:  1978-10

9.  Prognostic indicators in childhood IgA nephropathy.

Authors:  N Yoshikawa; H Ito; H Nakamura
Journal:  Nephron       Date:  1992       Impact factor: 2.847

10.  Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy.

Authors:  A C Allen; S J Harper; J Feehally
Journal:  Clin Exp Immunol       Date:  1995-06       Impact factor: 4.330
View more
  44 in total

Review 1.  Pediatric vasculitis.

Authors:  Ezgi Deniz Batu; Seza Ozen
Journal:  Curr Rheumatol Rep       Date:  2012-04       Impact factor: 4.592

2.  Recognition of galactose-deficient O-glycans in the hinge region of IgA1 by N-acetylgalactosamine-specific snail lectins: a comparative binding study.

Authors:  Michelle M Gomes; Hitoshi Suzuki; Monica T Brooks; Milan Tomana; Zina Moldoveanu; Jiri Mestecky; Bruce A Julian; Jan Novak; Andrew B Herr
Journal:  Biochemistry       Date:  2010-07-13       Impact factor: 3.162

3.  Toll-like receptors, immunoproteasome and regulatory T cells in children with Henoch-Schönlein purpura and primary IgA nephropathy.

Authors:  Maria Elena Donadio; Elisa Loiacono; Licia Peruzzi; Alessandro Amore; Roberta Camilla; Federica Chiale; Luca Vergano; Alberto Boido; Margherita Conrieri; Manuela Bianciotto; Francesca Maria Bosetti; Rosanna Coppo
Journal:  Pediatr Nephrol       Date:  2014-04-01       Impact factor: 3.714

Review 4.  Biomarkers in IgA nephropathy: relationship to pathogenetic hits.

Authors:  Margaret Colleen Hastings; Zina Moldoveanu; Hitoshi Suzuki; Francois Berthoux; Bruce A Julian; John T Sanders; Matthew B Renfrow; Jan Novak; Robert J Wyatt
Journal:  Expert Opin Med Diagn       Date:  2013-11

Review 5.  Glycosylation of IgA1 and pathogenesis of IgA nephropathy.

Authors:  Jan Novak; Bruce A Julian; Jiri Mestecky; Matthew B Renfrow
Journal:  Semin Immunopathol       Date:  2012-03-21       Impact factor: 9.623

6.  In vitro-generated immune complexes containing galactose-deficient IgA1 stimulate proliferation of mesangial cells.

Authors:  Takeshi Yanagihara; Rhubell Brown; Stacy Hall; Zina Moldoveanu; Alice Goepfert; Milan Tomana; Bruce A Julian; Jiri Mestecky; Jan Novak
Journal:  Results Immunol       Date:  2012-01-01

7.  Analysis of IgA1 N-glycosylation and its contribution to FcalphaRI binding.

Authors:  Michelle M Gomes; Stephanie B Wall; Kazuo Takahashi; Jan Novak; Matthew B Renfrow; Andrew B Herr
Journal:  Biochemistry       Date:  2008-10-01       Impact factor: 3.162

Review 8.  Systemic vasculitis in childhood.

Authors:  Abraham Gedalia; Raquel Cuchacovich
Journal:  Curr Rheumatol Rep       Date:  2009-12       Impact factor: 4.592

Review 9.  Pathogenesis of Henoch-Schönlein purpura nephritis.

Authors:  Keith K Lau; Hitoshi Suzuki; Jan Novak; Robert J Wyatt
Journal:  Pediatr Nephrol       Date:  2009-06-13       Impact factor: 3.714

Review 10.  Small vessel vasculitis.

Authors:  Paul Brogan; Despina Eleftheriou; Michael Dillon
Journal:  Pediatr Nephrol       Date:  2009-11-03       Impact factor: 3.714
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.