Literature DB >> 17943287

B cells in glomerulonephritis: focus on lupus nephritis.

Menna R Clatworthy1, Kenneth G C Smith.   

Abstract

The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated glomerulonephritis. However, it is increasingly appreciated that B cells play a much broader role in such diseases, functioning as antigen-presenting cells, regulators of T cells, dendritic cells, and macrophages and orchestrators of local lymphatic expansion. In this review, we provide an overview of basic B cell biology and consider the evidence implicating B cells in one of the archetypal immune-mediated glomerulonephritides, lupus nephritis.

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Year:  2007        PMID： 17943287     DOI： 10.1007/s00281-007-0092-1

Source DB:  PubMed          Journal:  Semin Immunopathol        ISSN： 1863-2297            Impact factor:   9.623


  186 in total

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Journal:  Nat Med       Date:  1999-06       Impact factor: 53.440

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Journal:  Hum Mol Genet       Date:  2005-08-22       Impact factor: 6.150

3.  Glomerular binding activity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV collagen complex.

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Journal:  J Immunol       Date:  1995-03-01       Impact factor: 5.422

4.  Accelerated Fas-mediated apoptosis of monocytes and maturing macrophages from patients with systemic lupus erythematosus: relevance to in vitro impairment of interaction with iC3b-opsonized apoptotic cells.

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Journal:  J Immunol       Date:  2001-11-15       Impact factor: 5.422

5.  Phagocytosis and clearance of apoptotic cells is mediated by MER.

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Journal:  Nature       Date:  2001-05-10       Impact factor: 49.962

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Journal:  Nature       Date:  1996-01-25       Impact factor: 49.962

Review 7.  Toll-like receptor activation in the pathogenesis of systemic lupus erythematosus.

Authors:  Terry K Means; Andrew D Luster
Journal:  Ann N Y Acad Sci       Date:  2005-12       Impact factor: 5.691

8.  Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10:interferon-gamma-secreting cells in the peripheral blood.

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Journal:  Arthritis Rheum       Date:  1996-03

9.  Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites.

Authors:  D V Vlahakos; M H Foster; S Adams; M Katz; A A Ucci; K J Barrett; S K Datta; M P Madaio
Journal:  Kidney Int       Date:  1992-06       Impact factor: 10.612

10.  Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase.

Authors:  Philip L Cohen; Roberto Caricchio; Valsamma Abraham; Todd D Camenisch; J Charles Jennette; Robert A S Roubey; H Shelton Earp; Glenn Matsushima; Elizabeth A Reap
Journal:  J Exp Med       Date:  2002-07-01       Impact factor: 14.307
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  7 in total

Review 1.  Biological therapy for lupus nephritis-tribulations and trials.

Authors:  Rona M Smith; Menna R Clatworthy; David R W Jayne
Journal:  Nat Rev Rheumatol       Date:  2010-07-20       Impact factor: 20.543

2.  Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.

Authors:  Masanori Iseki; Miyuki Omori-Miyake; Whitney Xu; Xiaocui Sun; Satoshi Takaki; David J Rawlings; Steven F Ziegler
Journal:  Int Immunol       Date:  2012-01-25       Impact factor: 4.823

Review 3.  B-cell depletion in the treatment of lupus nephritis.

Authors:  Jon W Gregersen; David R W Jayne
Journal:  Nat Rev Nephrol       Date:  2012-07-17       Impact factor: 28.314

Review 4.  Neutrophils: game changers in glomerulonephritis?

Authors:  Tanya N Mayadas; Florencia Rosetti; Thomas Ernandez; Sanjeev Sethi
Journal:  Trends Mol Med       Date:  2010-07-29       Impact factor: 11.951

5.  Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice.

Authors:  Alexander Jacob; Lee Chaves; Michael T Eadon; Anthony Chang; Richard J Quigg; Jessy J Alexander
Journal:  Immunology       Date:  2013-07       Impact factor: 7.397

Review 6.  Fcγ Receptors in Solid Organ Transplantation.

Authors:  Tomas Castro-Dopico; Menna R Clatworthy
Journal:  Curr Transplant Rep       Date:  2016-10-03

7.  Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis.

Authors:  Chenzhi Jing; Tomas Castro-Dopico; Nathan Richoz; Zewen K Tuong; John R Ferdinand; Laurence S C Lok; Kevin W Loudon; Gemma D Banham; Rebeccah J Mathews; Zaeem Cader; Susan Fitzpatrick; Kathleen R Bashant; Mariana J Kaplan; Arthur Kaser; Randall S Johnson; Michael P Murphy; Richard M Siegel; Menna R Clatworthy
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-15       Impact factor: 11.205
  7 in total

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