Literature DB >> 17943236

Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase.

S Jakob1, J Haendeler.   

Abstract

Aging is one major risk factor for the incidence of coronary artery disease and the development of atherosclerosis. The functional integrity of the endothelial cell monolayer is essential to prevent lesion formation. Endothelial cells show profound changes with age. However, the molecular mechanisms are not well understood. Important players in the process of endothelial cell aging are reactive oxygen species, nitric oxide bioavailability, mitochondrial integrity and the activity of telomerase reverse transcriptase. This review will demonstrate the evidence that these processes are involved in endothelial cell aging and linked to each other. The future goal of understanding endothelial cell aging would allow for an anti-aging therapy to reduce the influence of aging in the development of atherosclerosis and coronary artery disease.

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Year:  2007        PMID： 17943236     DOI： 10.1007/s00391-007-0482-y

Source DB:  PubMed          Journal:  Z Gerontol Geriatr        ISSN： 0948-6704            Impact factor:   1.281


  36 in total

Review 1.  Oxidants, oxidative stress and the biology of ageing.

Authors:  T Finkel; N J Holbrook
Journal:  Nature       Date:  2000-11-09       Impact factor: 49.962

2.  Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide.

Authors:  J Hoffmann; J Haendeler; A Aicher; L Rössig; M Vasa; A M Zeiher; S Dimmeler
Journal:  Circ Res       Date:  2001-10-12       Impact factor: 17.367

3.  Alterations of nitric oxide synthase expression with aging and hypertension in rats.

Authors:  T C Chou; M H Yen; C Y Li; Y A Ding
Journal:  Hypertension       Date:  1998-02       Impact factor: 10.190

4.  Decline in skeletal muscle mitochondrial function with aging in humans.

Authors:  Kevin R Short; Maureen L Bigelow; Jane Kahl; Ravinder Singh; Jill Coenen-Schimke; Sreekumar Raghavakaimal; K Sreekumaran Nair
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-30       Impact factor: 11.205

5.  Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation.

Authors:  Judith Haendeler; Jörg Hoffmann; Sandy Rahman; Andreas M Zeiher; Stefanie Dimmeler
Journal:  FEBS Lett       Date:  2003-02-11       Impact factor: 4.124

6.  Flow-induced vascular remodeling in the rat carotid artery diminishes with age.

Authors:  J K Miyashiro; V Poppa; B C Berk
Journal:  Circ Res       Date:  1997-09       Impact factor: 17.367

7.  Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction.

Authors:  Tohru Minamino; Hideaki Miyauchi; Toshihiko Yoshida; Yasuo Ishida; Hideo Yoshida; Issei Komuro
Journal:  Circulation       Date:  2002-04-02       Impact factor: 29.690

8.  Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy.

Authors:  Dong You; Ludovic Waeckel; Téni G Ebrahimian; Olivier Blanc-Brude; Philippe Foubert; Véronique Barateau; Micheline Duriez; Sophie Lericousse-Roussanne; José Vilar; Elisabetta Dejana; Gérard Tobelem; Bernard I Lévy; Jean-Sébastien Silvestre
Journal:  Circulation       Date:  2006-07-17       Impact factor: 29.690

9.  The role of endothelial injury and platelet and macrophage interactions in atherosclerosis.

Authors:  R Ross; A Faggiotto; D Bowen-Pope; E Raines
Journal:  Circulation       Date:  1984-11       Impact factor: 29.690

10.  Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.

Authors:  Judith Haendeler; Jörg Hoffmann; J Florian Diehl; Mariuca Vasa; Ioakim Spyridopoulos; Andreas M Zeiher; Stefanie Dimmeler
Journal:  Circ Res       Date:  2004-02-12       Impact factor: 17.367
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  4 in total

Review 1.  Mechanisms of dysfunction in senescent pulmonary endothelium.

Authors:  Daniel Jane-Wit; Hyung J Chun
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-03-05       Impact factor: 6.053

2.  Potential involvement of LOX-1 in functional consequences of endothelial senescence.

Authors:  Magomed Khaidakov; Xianwei Wang; Jawahar L Mehta
Journal:  PLoS One       Date:  2011-06-15       Impact factor: 3.240

3.  A meta-analysis of genome-wide association studies of epigenetic age acceleration.

Authors:  Jude Gibson; Tom C Russ; Toni-Kim Clarke; David M Howard; Robert F Hillary; Kathryn L Evans; Rosie M Walker; Mairead L Bermingham; Stewart W Morris; Archie Campbell; Caroline Hayward; Alison D Murray; David J Porteous; Steve Horvath; Ake T Lu; Andrew M McIntosh; Heather C Whalley; Riccardo E Marioni
Journal:  PLoS Genet       Date:  2019-11-18       Impact factor: 5.917

Review 4.  Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes.

Authors:  Anna A Plyasova; Dmitry D Zhdanov
Journal:  Biomedicines       Date:  2021-05-09
  4 in total

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