Literature DB >> 17942309

Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.

Tom D Heightman1, Jackie S Scott, Mark Longley, Vincent Bordas, David K Dean, Richard Elliott, Gail Hutley, Jason Witherington, Lee Abberley, Barry Passingham, Manuela Berlanga, Maite de Los Frailes, Alan Wise, Ben Powney, Alison Muir, Fiona McKay, Sharon Butler, Kim Winborn, Christopher Gardner, Jill Darton, Colin Campbell, Gareth Sanger.   

Abstract

High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats.

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Year:  2007        PMID: 17942309     DOI: 10.1016/j.bmcl.2007.09.067

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Cognitive enhancing effects of ghrelin receptor agonists.

Authors:  Zeenat Atcha; Woei-Shin Chen; Agnes B Ong; Fong-Kuan Wong; Aveline Neo; Edward R Browne; Jason Witherington; Darrel J Pemberton
Journal:  Psychopharmacology (Berl)       Date:  2009-08-04       Impact factor: 4.530

2.  The ChEMBL bioactivity database: an update.

Authors:  A Patrícia Bento; Anna Gaulton; Anne Hersey; Louisa J Bellis; Jon Chambers; Mark Davies; Felix A Krüger; Yvonne Light; Lora Mak; Shaun McGlinchey; Michal Nowotka; George Papadatos; Rita Santos; John P Overington
Journal:  Nucleic Acids Res       Date:  2013-11-07       Impact factor: 16.971

  2 in total

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