Literature DB >> 17942304

Synthesis of phosphorothioate oligonucleotide-peptide conjugates by solid phase fragment condensation.

Irmina Diala1, Akira Osada, Shinji Maruoka, Takashi Imanisi, Satoshi Murao, Taishi Ato, Hideki Ohba, Masayuki Fujii.   

Abstract

Phosphorothioate oligonucleotide-peptide conjugates were synthesized by solid phase fragment condensation (SPFC). Arginine rich peptides could be successfully conjugated in 2.8-13.4% isolated yields. All the products were fully characterized by reversed phase HPLC and MALDI-TOF-MS to give satisfactory results.

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Year:  2007        PMID: 17942304     DOI: 10.1016/j.bmcl.2007.09.101

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  An activated triple bond linker enables 'click' attachment of peptides to oligonucleotides on solid support.

Authors:  Malgorzata Wenska; Margarita Alvira; Peter Steunenberg; Asa Stenberg; Merita Murtola; Roger Strömberg
Journal:  Nucleic Acids Res       Date:  2011-07-27       Impact factor: 16.971

2.  Novel Convenient Approach to the Solid-Phase Synthesis of Oligonucleotide Conjugates.

Authors:  Mariya I Meschaninova; Darya S Novopashina; Olga A Semikolenova; Vladimir N Silnikov; Alya G Venyaminova
Journal:  Molecules       Date:  2019-11-22       Impact factor: 4.411

  2 in total

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