| Literature DB >> 17942086 |
Yanfei Huang1, Hamid Rabb, Karl L Womer.
Abstract
The pathogenesis of ischemia-reperfusion injury (IRI) is complex and not well understood. Inflammation plays an important role in IRI, with involvement of leukocytes, adhesion molecules, chemokines and cytokines. Emerging data suggest a role of T cells as mediators of IRI both in renal and extra-renal organs. Divergent roles of T cell subsets have also been elucidated, suggesting a more complicated role of T cells in the different phases of IRI. This review presents recent evidence from various animal models that advances our understanding of the role T cells play in IRI. These findings entertain the possibility of using immunotherapeutic agents for the prevention and treatment of IRI.Entities:
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Year: 2007 PMID: 17942086 PMCID: PMC2211448 DOI: 10.1016/j.cellimm.2007.03.009
Source DB: PubMed Journal: Cell Immunol ISSN: 0008-8749 Impact factor: 4.868