| Literature DB >> 17941638 |
Angelique M C Lokate1, J Bianca Beusink, Geert A J Besselink, Ger J M Pruijn, Richard B M Schasfoort.
Abstract
A new commercial surface plasmon resonance (SPR) imaging analysis system with a novel SPR dip angle scanning principle allows the measurement, without the need for labeling, of the exact SPR dip angle. With this system hundreds of biomolecular interactions can be monitored on microarrays simultaneously and with great precision. The potency of this system is demonstrated by automatically monitoring the interactions between citrullinated peptides and serum autoantibodies of 50 rheumatoid arthritis (RA) patients and 29 controls in a single step. The smallest antibody concentration that could be measured in this experimental setup was 0.5 pM.Entities:
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Year: 2007 PMID： 17941638 DOI： 10.1021/ja075103x
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419