Marc Mayberg1, Sandra Vermeulen. 1. Neurological Surgery, Swedish Neuroscience Institute, Seattle, Washington 98122, USA. Marc.Mayberg@swedish.org
Abstract
PURPOSE OF REVIEW: Stereotactic radiosurgery has become the preferred radiation treatment modality for secreting and nonsecreting pituitary adenomas, although randomized studies comparing delivery systems, fractionation and dose have not been performed. RECENT FINDINGS: The technical achievement of radiosurgery delivery systems has minimized the radiation dose to surrounding normal tissue compared with external beam radiotherapy. With a reduction in acute and chronic side effects, the total dose to abnormal tissue can be increased allowing for greater tumor control. SUMMARY: The radiobiology, control rates and normal tissue tolerances of stereotactic radiosurgery in the treatment of pituitary adenomas is reviewed.
PURPOSE OF REVIEW: Stereotactic radiosurgery has become the preferred radiation treatment modality for secreting and nonsecreting pituitary adenomas, although randomized studies comparing delivery systems, fractionation and dose have not been performed. RECENT FINDINGS: The technical achievement of radiosurgery delivery systems has minimized the radiation dose to surrounding normal tissue compared with external beam radiotherapy. With a reduction in acute and chronic side effects, the total dose to abnormal tissue can be increased allowing for greater tumor control. SUMMARY: The radiobiology, control rates and normal tissue tolerances of stereotactic radiosurgery in the treatment of pituitary adenomas is reviewed.
Authors: Debraj Mukherjee; Hasan A Zaidi; Thomas A Kosztowski; Aditya Halthore; George I Jallo; Roberto Salvatori; David C Chang; Alfredo Quiñones-Hinojosa Journal: Childs Nerv Syst Date: 2009-11-10 Impact factor: 1.475