PURPOSE: State Gentamicin antibiotic prophylaxis is contraindicated in 25 gauge Transconjunctival Sutureless Vitrectomy. METHODS: A 75-year-old diabetic woman was affected by glaucoma and mild diabetic retinopathy in both eyes, and epiretinal membrane in the left eye. A 25-gauge Transconjunctival Sutureless Vitrectomy (TSV) was performed with self-sealing transconjunctival scletomies of the left eye. Post-operation antibiotic prophylaxis was obtained by subconconjunctival injection of Gentamicin sulfate (0.4 mg/ml) adjacent to scletomies. RESULTS: A month after the operation visual acuity had not recovered. Fluorescein angiography detected occlusion of perifoveal capillaries. CONCLUSION: Antibiotics, in particular gentamicin, have the potential to cause significant ocular toxicity when they gain access to the inside of the eye, through thinned sclera or sutureless sclerotomies of TSV.
PURPOSE: State Gentamicin antibiotic prophylaxis is contraindicated in 25 gauge Transconjunctival Sutureless Vitrectomy. METHODS: A 75-year-old diabeticwoman was affected by glaucoma and mild diabetic retinopathy in both eyes, and epiretinal membrane in the left eye. A 25-gauge Transconjunctival Sutureless Vitrectomy (TSV) was performed with self-sealing transconjunctival scletomies of the left eye. Post-operation antibiotic prophylaxis was obtained by subconconjunctival injection of Gentamicin sulfate (0.4 mg/ml) adjacent to scletomies. RESULTS: A month after the operation visual acuity had not recovered. Fluorescein angiography detected occlusion of perifoveal capillaries. CONCLUSION: Antibiotics, in particular gentamicin, have the potential to cause significant ocular toxicity when they gain access to the inside of the eye, through thinned sclera or sutureless sclerotomies of TSV.
Authors: M Mannerström; M Zorn-Kruppa; H Diehl; M Engelke; T Toimela; H Mäenpää; A Huhtala; H Uusitalo; L Salminen; P Pappas; M Marselos; M Mäntylä; E Mäntylä; H Tähti Journal: Toxicol In Vitro Date: 2002-04 Impact factor: 3.500
Authors: Gildo Y Fujii; Eugene De Juan; Mark S Humayun; Tom S Chang; Dante J Pieramici; Aaron Barnes; David Kent Journal: Ophthalmology Date: 2002-10 Impact factor: 12.079