[Comparison of the inhibitory effects of a psychostimulant of the sydnonimine series on the development of stress and ethanol induced lesions in the rat gastric mucosa].

The possibility of the inhibitory influence of one of the psychostimulators of sydnonimine derivatives OF 743 on stress--and ethanol-induced mucosal lesions was studied in rats. Large doses (15 mg/kg) OF 743, which induced both central, psychostimulator, peripheral, and vagolytic effects equally decrease stress- and ethanol-induced mucosal lesions. The smaller doses, which show only peripheral effects, largely inhibit ethanol-induced lesions. The degree of the inhibitory influence of OF 743 is comparable with the same atropine influence and considerably exceeds the degree of the inhibitory influence of pirenzepine.