Literature DB >> 17937972

Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones.

Fabrice Bailly1, Clémence Queffélec, Gladys Mbemba, Jean-François Mouscadet, Nicole Pommery, Jean Pommery, Jean-Pierre Hénichart, Philippe Cotelle.   

Abstract

A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test.

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Year:  2007        PMID: 17937972     DOI: 10.1016/j.ejmech.2007.08.005

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  4 in total

1.  3-(2-Bromo-eth-oxy)-4-(4-bromo-phen-yl)furan-5(2H)-one.

Authors:  Zhu-Ping Xiao; Wen-Bin Yan; Zhu-Xiang Liu; Li-Hua Chen; Xiao-Chun Peng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-11-06

2.  3-Chloro-4-dimethyl-amino-5-[(1R,2S,5R)-2-isopropyl-5-methyl-cyclo-hex-yloxy]furan-2(5H)-one.

Authors:  Xiu-Mei Song; Ning Wang; Zhao-Yang Wang; Zong-Cai Feng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-05-20

3.  3-(4-Bromo-phen-yl)-4-(4-hy-droxy-anilino)furan-2(5H)-one.

Authors:  Wanxi Peng; Lansheng Wang; Fengjuan Wu; Qiu Xu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-08-11

4.  Quinoline based furanones and their nitrogen analogues: Docking, synthesis and biological evaluation.

Authors:  Sukhbir Lal Khokra; Pawan Kaushik; M M Alam; M S Zaman; Aftab Ahmad; Shah Alam Khan; Asif Husain
Journal:  Saudi Pharm J       Date:  2015-06-11       Impact factor: 4.330

  4 in total

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