Literature DB >> 17936669

Poly(ADP-ribose) makes a date with death.

James T Heeres1, Paul J Hergenrother.   

Abstract

Poly(ADP-ribose) polymerase (PARP) enzymes catalyze the conversion of NAD(+) to polymers of poly(ADP-ribose) (PAR). Although its role in the DNA-damage response has long been recognized, recent work indicates that PAR itself acts at the mitochondria to directly induce cell death through stimulation of apoptosis-inducing factor (AIF) release. This review discusses PAR synthesis and degradation, and the role of PAR misregulation in various disease states. Attention is given to opportunities for therapeutic intervention with small molecules that are involved in PAR signaling, with specific focus on poly(ADP-ribose) glycohydrolase (PARG) and AIF.

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Year:  2007        PMID： 17936669     DOI： 10.1016/j.cbpa.2007.08.038

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  58 in total

1.  Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase.

Authors:  Davide Botta; Myron K Jacobson
Journal:  Biochemistry       Date:  2010-09-07       Impact factor: 3.162

2.  Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins.

Authors:  Veronica C Ardi; Leslie D Alexander; Victoria A Johnson; Shelli R McAlpine
Journal:  ACS Chem Biol       Date:  2011-10-17       Impact factor: 5.100

3.  Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.

Authors:  Seamus Morrone; Zhihong Cheng; Randall T Moon; Feng Cong; Wenqing Xu
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

Review 4.  Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.

Authors:  Key-Hwan Lim; Myoung-Hyun Song; Kwang-Hyun Baek
Journal:  Cell Mol Life Sci       Date:  2016-01-13       Impact factor: 9.261

5.  Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.

Authors:  Claire M Payne; Cheray Crowley-Skillicorn; Carol Bernstein; Hana Holubec; Harris Bernstein
Journal:  Clin Exp Gastroenterol       Date:  2011-05-03

6.  Histone deacetylase inhibitor belinostat represses survivin expression through reactivation of transforming growth factor beta (TGFbeta) receptor II leading to cancer cell death.

Authors:  Sanjib Chowdhury; Gillian M Howell; Carol A Teggart; Aparajita Chowdhury; Jonathan J Person; Dawn M Bowers; Michael G Brattain
Journal:  J Biol Chem       Date:  2011-07-08       Impact factor: 5.157

7.  A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors.

Authors:  Leo L Chan; Maria Pineda; James T Heeres; Paul J Hergenrother; Brian T Cunningham
Journal:  ACS Chem Biol       Date:  2008-07-18       Impact factor: 5.100

Review 8.  Mechanisms of DNA damage, repair, and mutagenesis.

Authors:  Nimrat Chatterjee; Graham C Walker
Journal:  Environ Mol Mutagen       Date:  2017-05-09       Impact factor: 3.216

9.  Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death.

Authors:  Jeong Ho Seok; Kyeong Ah Park; Hee Sun Byun; Minho Won; Sanghee Shin; Byung-Lyul Choi; Hyunji Lee; Young-Rae Kim; Jang Hee Hong; Jongsun Park; Gang Min Hur
Journal:  Korean J Physiol Pharmacol       Date:  2008-08-31       Impact factor: 2.016

Review 10.  Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.

Authors:  Ashok Agarwal; Reda Z Mahfouz; Rakesh K Sharma; Oli Sarkar; Devna Mangrola; Premendu P Mathur
Journal:  Reprod Biol Endocrinol       Date:  2009-12-05       Impact factor: 5.211
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