| Literature DB >> 17936631 |
Kwangwoo Chun1, Song-Kyu Park, Hwan Mook Kim, Yongseok Choi, Myung-Hwa Kim, Chun-Ho Park, Bo-Young Joe, Tae Gyu Chun, Hyun-Moo Choi, Hee-Yoon Lee, Sung Hee Hong, Myung Sook Kim, Ky-Youb Nam, Gyoonhee Han.
Abstract
A series of coumarin types MMP inhibitors were designed based on gelastatin hydroxamates (1) and evaluated for TACE, cellular TNF-alpha, and NO inhibitory activities. Among them, compounds 9b had potent inhibitory activities in enzymatic and cellular assays and good selectivity to MMP-2 and MMP-9. Further investigation of 9b will be carried out for its efficacy in RA animal model system.Entities:
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Year: 2007 PMID： 17936631 DOI： 10.1016/j.bmc.2007.09.014
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641