Literature DB >> 17935939

[Subarachnoid haemorrhage: epidemiology, genomic, clinical presentation].

G Audibert1, S Bousquet, C Charpentier, Y Devaux, P-M Mertes.   

Abstract

Subarachnoid haemorrhage (SAH) accounts for 1 to 7% of all strokes. In France, the range of incidence of SAH varies between 3 and 8/100,000 inhabitants. Global mortality lies around 40%, including 70% during the first week. The size of more than 90% of all aneurysms is less than 10 mm. In more than 90% of the patients; SAH is sporadic and a familial screening is warranted only after SAH occurring in 2 first-degree relatives. The main risk factors of SAH are tobacco, arterial hypertension and alcohol abuse. Genetic susceptibility may exist: it could involve several genes, the expression of which would characterize pathophysiological pathways implicated in the disease. This could be identified using genomic technique of microarrays, which could explore all the genome, simply using a sample of peripheral venous blood. For example, in the future, this approach could help to identify patients who are at high risk to develop vasospasm after SAH.

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Year:  2007        PMID: 17935939     DOI: 10.1016/j.annfar.2007.09.006

Source DB:  PubMed          Journal:  Ann Fr Anesth Reanim        ISSN: 0750-7658


  2 in total

Review 1.  Suggested connections between risk factors of intracranial aneurysms: a review.

Authors:  Juan R Cebral; Marcelo Raschi
Journal:  Ann Biomed Eng       Date:  2012-12-14       Impact factor: 3.934

2.  Spontaneous Elevation of Blood Pressure After SAH: An Epiphenomenon of Disease Severity and Demand, But Not a Surrogate for Outcome?

Authors:  F Teping; W Albanna; H Clusmann; H Schulze-Steinen; M Mueller; A Hoellig; G A Schubert
Journal:  Neurocrit Care       Date:  2018-10       Impact factor: 3.210

  2 in total

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