| Literature DB >> 17933439 |
Kuichun Zhu1, Hong Qin, Soung-Chul Cha, Sattva S Neelapu, Willem Overwijk, Gregory A Lizee, James L Abbruzzese, Patrick Hwu, Laszlo Radvanyi, Larry W Kwak, David Z Chang.
Abstract
We investigated the antitumor effect of survivin DNA vaccine in murine pancreatic and lymphoma models, and if xenogenic survivin can generate stronger immune response. We found that mice vaccinated with either human or mouse survivin DNA have significantly slower tumor growth and longer survival than those vaccinated with vector DNA. There was no significant difference between groups that received human and mouse survivin DNA. Lymphocyte infiltration was greater in tumors of mice immunized with survivin DNA than in tumors of control mice. We conclude that survivin DNA vaccine generated specific antitumor effects with increased lymphocyte infiltration at the tumor sites.Entities:
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Year: 2007 PMID： 17933439 DOI： 10.1016/j.vaccine.2007.08.050
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641