BACKGROUND: Primary diffuse large B-cell lymphoma (DLBCL) of breast is rare. We aimed to define clinical features, prognostic factors, patterns of failure, and treatment outcomes. PATIENTS AND METHODS: A retrospective international study of 204 eligible patients presenting to the International Extranodal Lymphoma Study Group-affiliated institutions from 1980 to 2003. RESULTS: Median age was 64 years, with 95% of patients presenting with unilateral disease. Median overall survival (OS) was 8.0 years, and median progression-free survival 5.5 years. In multifactor analysis, favourable International Prognostic Index score, anthracycline-containing chemotherapy, and radiotherapy (RT) were significantly associated with longer OS (each P < or = 0.03). There was no benefit from mastectomy, as opposed to biopsy or lumpectomy only. At a median follow-up time of 5.5 years, 37% of patients had progressed--16% in the same or contralateral breast, 5% in the central nervous system, and 14% in other extranodal sites. CONCLUSIONS: The combination of limited surgery, anthracycline-containing chemotherapy, and involved-field RT produced the best outcome in the pre-rituximab era. A prospective trial on the basis of these results should be pursued to confirm these observations and to determine whether the impact of rituximab on the patterns of relapse and outcome parallels that of DLBCL presenting at other sites.
BACKGROUND: Primary diffuse large B-cell lymphoma (DLBCL) of breast is rare. We aimed to define clinical features, prognostic factors, patterns of failure, and treatment outcomes. PATIENTS AND METHODS: A retrospective international study of 204 eligible patients presenting to the International Extranodal Lymphoma Study Group-affiliated institutions from 1980 to 2003. RESULTS: Median age was 64 years, with 95% of patients presenting with unilateral disease. Median overall survival (OS) was 8.0 years, and median progression-free survival 5.5 years. In multifactor analysis, favourable International Prognostic Index score, anthracycline-containing chemotherapy, and radiotherapy (RT) were significantly associated with longer OS (each P < or = 0.03). There was no benefit from mastectomy, as opposed to biopsy or lumpectomy only. At a median follow-up time of 5.5 years, 37% of patients had progressed--16% in the same or contralateral breast, 5% in the central nervous system, and 14% in other extranodal sites. CONCLUSIONS: The combination of limited surgery, anthracycline-containing chemotherapy, and involved-field RT produced the best outcome in the pre-rituximab era. A prospective trial on the basis of these results should be pursued to confirm these observations and to determine whether the impact of rituximab on the patterns of relapse and outcome parallels that of DLBCL presenting at other sites.
Authors: S Rizzo; L Preda; G Villa; S Brambilla; G Pruneri; A Alietti; E Cassano; G Martinelli; M Bellomi Journal: Radiol Med Date: 2009-06-26 Impact factor: 3.469
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Authors: Peter J Hosein; Jocelyn C Maragulia; Matthew P Salzberg; Oliver W Press; Thomas M Habermann; Julie M Vose; Martin Bast; Ranjana H Advani; Robert Tibshirani; Andrew M Evens; Nahida Islam; John P Leonard; Peter Martin; Andrew D Zelenetz; Izidore S Lossos Journal: Br J Haematol Date: 2014-01-27 Impact factor: 6.998
Authors: Nicola Avenia; Alessandro Sanguinetti; Roberto Cirocchi; Giovanni Bistoni; Stefano Trastulli; Fabio D'Ajello; Francesco Barberini; Giuseppe Cavallaro; Antonio Rulli; Angelo Sidoni; Giuseppe Noya; Giorgio De Toma; Francesco Sciannameo Journal: World J Surg Oncol Date: 2010-06-28 Impact factor: 2.754
Authors: Narcis Octavian Zarnescu; Andreea Iliesiu; Alexandru Procop; Mircea Tampa; Clara Matei; Maria Sajin; Mariana Costache; Adrian Dumitru; Anca Mihaela Lazaroiu Journal: Maedica (Buchar) Date: 2015-03