RATIONALE: Evidence is emerging that exposure to maternal distress in early life plays a causal role in the development of childhood asthma. OBJECTIVES: Because much of the data are from high-risk cohorts, we undertook a birth cohort study in a complete population of children to test this association. METHODS: Using Manitoba, Canada's, health care and prescription databases, this longitudinal study assessed the association between maternal distress during the first year of life and onward, and asthma at age 7 in a 1995 birth cohort of 13,907 children. MEASUREMENTS AND MAIN RESULTS: Maternal distress was defined on the basis of health care or prescription medication use for depression or anxiety. Asthma status was derived from health care and prescription records for asthma, using a definition validated by comparison to pediatric allergist diagnosis. Multiple logistic regression was used to determine the likelihood of asthma (odds ratio [OR], 95% confidence interval [95% CI]). Independent of well-known asthma risk factors, our population-based study of a non-high-risk cohort demonstrated an increased risk of childhood asthma (OR, 1.25; 95% CI, 1.01-1.55) among children exposed to continued maternal distress from birth until age 7. Exposure to maternal depression and anxiety limited to the first year of life did not have a demonstrable association with subsequent asthma. Of interest, we observed that the risk of asthma associated with continued maternal distress was increased in children living in high- versus low-income households (OR, 1.44; 95% CI, 1.12-1.85). CONCLUSIONS: Maternal distress in early life plays a role in the development of childhood asthma, especially if it continues beyond the postpartum period.
RATIONALE: Evidence is emerging that exposure to maternal distress in early life plays a causal role in the development of childhood asthma. OBJECTIVES: Because much of the data are from high-risk cohorts, we undertook a birth cohort study in a complete population of children to test this association. METHODS: Using Manitoba, Canada's, health care and prescription databases, this longitudinal study assessed the association between maternal distress during the first year of life and onward, and asthma at age 7 in a 1995 birth cohort of 13,907 children. MEASUREMENTS AND MAIN RESULTS: Maternal distress was defined on the basis of health care or prescription medication use for depression or anxiety. Asthma status was derived from health care and prescription records for asthma, using a definition validated by comparison to pediatric allergist diagnosis. Multiple logistic regression was used to determine the likelihood of asthma (odds ratio [OR], 95% confidence interval [95% CI]). Independent of well-known asthma risk factors, our population-based study of a non-high-risk cohort demonstrated an increased risk of childhood asthma (OR, 1.25; 95% CI, 1.01-1.55) among children exposed to continued maternal distress from birth until age 7. Exposure to maternal depression and anxiety limited to the first year of life did not have a demonstrable association with subsequent asthma. Of interest, we observed that the risk of asthma associated with continued maternal distress was increased in children living in high- versus low-income households (OR, 1.44; 95% CI, 1.12-1.85). CONCLUSIONS: Maternal distress in early life plays a role in the development of childhood asthma, especially if it continues beyond the postpartum period.
Authors: Denise Daley; Mathieu Lemire; Loubna Akhabir; Moira Chan-Yeung; Jian Qing He; Treena McDonald; Andrew Sandford; Dorota Stefanowicz; Ben Tripp; David Zamar; Yohan Bosse; Vincent Ferretti; Alexandre Montpetit; Marie-Catherine Tessier; Allan Becker; Anita L Kozyrskyj; John Beilby; Pamela A McCaskie; Bill Musk; Nicole Warrington; Alan James; Catherine Laprise; Lyle J Palmer; Peter D Paré; Thomas J Hudson Journal: Hum Genet Date: 2009-02-27 Impact factor: 4.132
Authors: Jonathan M Feldman; Alexander N Ortega; Daphne Koinis-Mitchell; Alice A Kuo; Glorisa Canino Journal: J Nerv Ment Dis Date: 2010-04 Impact factor: 2.254
Authors: Anita L Kozyrskyj; Garth E Kendall; Peter Jacoby; Peter D Sly; Stephen R Zubrick Journal: Am J Public Health Date: 2009-08-20 Impact factor: 9.308