| Literature DB >> 17931866 |
Zhong Zhao1, Gian Luca Araldi, Yufang Xiao, Adulla P Reddy, Yihua Liao, Srinivasa Karra, Nadia Brugger, David Fischer, Elizabeth Palmer.
Abstract
Replacement of the hydroxy cyclopentanone ring in PGE(2) with chemically more stable heterocyclic rings and substitution of the unsaturated alpha-alkenyl chain with a metabolically more stable phenethyl chain led to the development of potent and selective analogs of PGE(2). Compound 10f showed the highest potency and selectivity for EP(4) the receptor.Entities:
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Year: 2007 PMID： 17931866 DOI： 10.1016/j.bmcl.2007.09.074
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823