| Literature DB >> 17931863 |
Philip J Skinner1, Martin C Cherrier, Peter J Webb, Carleton R Sage, Huong T Dang, Cameron C Pride, Ruoping Chen, Susan Y Tamura, Jeremy G Richman, Daniel T Connolly, Graeme Semple.
Abstract
A series of 3-nitro-4-substituted-aminobenzoic acids were prepared and found to act as potent and highly selective agonists of the orphan human GPCR GPR109b, a low affinity receptor for niacin. No activity was observed at the closely homologous high affinity niacin receptor, GPR109a. A second series, comprising 6-amino-substituted nicotinic acids was, also prepared and several analogues showed comparable activity to the nitroaryl series.Entities:
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Year: 2007 PMID： 17931863 DOI： 10.1016/j.bmcl.2007.09.058
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823