OBJECTIVE: To examine the effect of the I405V and TaqIB polymorphisms of cholesteryl ester transfer protein (CETP) on the lipid response after simvastatin treatment in 180 hypercholesterolaemic patients. METHODS: Hypercholesterolaemic patients (n = 180) attending the lipid clinic at the Onassis Cardiac Surgery Center were genotyped and their response to simvastatin was evaluated. RESULTS: Sequence variations in the CETP gene influenced the effect of lipid-lowering treatment. Specifically, the I allele of the I405V polymorphism was associated with a greater reduction in triglyceride (TG; p = 0.04) and a significant increase in high-density lipoprotein cholesterol (HDL-C) levels (p = 0.05) after treatment compared with the V allele. CONCLUSIONS: The authors' findings suggest that CETP I405V polymorphism modifies the effect of simvastatin on TG reduction and HDL-C elevation; the carriers of the I allele responded better to treatment. These findings need to be confirmed in larger studies.
OBJECTIVE: To examine the effect of the I405V and TaqIB polymorphisms of cholesteryl ester transfer protein (CETP) on the lipid response after simvastatin treatment in 180 hypercholesterolaemic patients. METHODS: Hypercholesterolaemic patients (n = 180) attending the lipid clinic at the Onassis Cardiac Surgery Center were genotyped and their response to simvastatin was evaluated. RESULTS: Sequence variations in the CETP gene influenced the effect of lipid-lowering treatment. Specifically, the I allele of the I405V polymorphism was associated with a greater reduction in triglyceride (TG; p = 0.04) and a significant increase in high-density lipoprotein cholesterol (HDL-C) levels (p = 0.05) after treatment compared with the V allele. CONCLUSIONS: The authors' findings suggest that CETPI405V polymorphism modifies the effect of simvastatin on TG reduction and HDL-C elevation; the carriers of the I allele responded better to treatment. These findings need to be confirmed in larger studies.
Authors: Genovefa Kolovou; Georgia Ragia; Vana Kolovou; Constantinos Mihas; Niki Katsiki; Ioannis Vasiliadis; Sophie Mavrogeni; Vassiliki Vartela; Anna Tavridou; Vangelis G Manolopoulos Journal: Open Cardiovasc Med J Date: 2014-02-07
Authors: Iris Postmus; Helen R Warren; Stella Trompet; Benoit J Arsenault; Christy L Avery; Joshua C Bis; Daniel I Chasman; Catherine E de Keyser; Harshal A Deshmukh; Daniel S Evans; QiPing Feng; Xiaohui Li; Roelof A J Smit; Albert V Smith; Fangui Sun; Kent D Taylor; Alice M Arnold; Michael R Barnes; Bryan J Barratt; John Betteridge; S Matthijs Boekholdt; Eric Boerwinkle; Brendan M Buckley; Y-D Ida Chen; Anton J M de Craen; Steven R Cummings; Joshua C Denny; Marie Pierre Dubé; Paul N Durrington; Gudny Eiriksdottir; Ian Ford; Xiuqing Guo; Tamara B Harris; Susan R Heckbert; Albert Hofman; G Kees Hovingh; John J P Kastelein; Leonore J Launer; Ching-Ti Liu; Yongmei Liu; Thomas Lumley; Paul M McKeigue; Patricia B Munroe; Andrew Neil; Deborah A Nickerson; Fredrik Nyberg; Eoin O'Brien; Christopher J O'Donnell; Wendy Post; Neil Poulter; Ramachandran S Vasan; Kenneth Rice; Stephen S Rich; Fernando Rivadeneira; Naveed Sattar; Peter Sever; Sue Shaw-Hawkins; Denis C Shields; P Eline Slagboom; Nicholas L Smith; Joshua D Smith; Nona Sotoodehnia; Alice Stanton; David J Stott; Bruno H Stricker; Til Stürmer; André G Uitterlinden; Wei-Qi Wei; Rudi G J Westendorp; Eric A Whitsel; Kerri L Wiggins; Russell A Wilke; Christie M Ballantyne; Helen M Colhoun; L Adrienne Cupples; Oscar H Franco; Vilmundur Gudnason; Graham Hitman; Colin N A Palmer; Bruce M Psaty; Paul M Ridker; Jeanette M Stafford; Charles M Stein; Jean-Claude Tardif; Mark J Caulfield; J Wouter Jukema; Jerome I Rotter; Ronald M Krauss Journal: J Med Genet Date: 2016-09-01 Impact factor: 6.318