Literature DB >> 1793047

Effects of the prostaglandin analogue misoprostol on inflammatory mediator release by human monocytes.

D L Widomski1, R E Walsh, D A Baron, M I Hidvegi, D J Fretland, P W Collins, T S Gaginella.   

Abstract

The effect of misoprostol (M) on IL-1 beta, TNF-alpha, and lipid mediator release (assessed by RIA) by adherent (assessed by electron microscopy) human monocytes were studied in vitro. Human monocytes stimulated with E. Coli-derived lipopolysaccharide showed an increase in both IL-1 beta and TNF-alpha release. Incubation of the monocytes with LPS and M (18 hrs.), resulted in a reduction of both IL-1 beta and TNF-alpha levels. Leukotriene B4 levels did not increase in response to LPS or M. LPS also caused an increase in thromboxane (TXB2). M decreased TXB2 levels. 6-keto PGF1 alpha (6KP). Incubation with LPS and M stimulated release. LPS caused an increase in PGE2 levels. M (100 microM) caused an increase in PGE2 levels, M (1 microM) had no effect on PGE2. These data suggest a possible immunomodulatory role for misoprostol in inflammatory diseases.

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Year:  1991        PMID： 1793047     DOI： 10.1007/bf01993229

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  5 in total

Review 1.  More selective ligands at eicosanoid receptor subtypes improve prospects in inflammatory and cardiovascular research.

Authors:  H Giles
Journal:  Trends Pharmacol Sci       Date:  1990-08       Impact factor: 14.819

Review 2.  Misoprostol: discovery, development, and clinical applications.

Authors:  P W Collins
Journal:  Med Res Rev       Date:  1990 Apr-Jun       Impact factor: 12.944

3.  Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

Authors:  P H Hart; G F Vitti; D R Burgess; G A Whitty; D S Piccoli; J A Hamilton
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

4.  A new method for the purification of human eosinophils and neutrophils, and a comparison of the ability of these cells to damage schistosomula of Schistosoma mansoni.

Authors:  M A Vadas; J R David; A Butterworth; N T Pisani; T A Siongok
Journal:  J Immunol       Date:  1979-04       Impact factor: 5.422

5.  Effects of prostaglandins and cAMP levels on monocyte IL-1 production.

Authors:  S Kassis; J C Lee; N Hanna
Journal:  Agents Actions       Date:  1989-06
  5 in total
  3 in total

1.  Neither vaginal nor buccal administration of 800 μg misoprostol alters mucosal and systemic immune activation or the cervicovaginal microbiome: a pilot study.

Authors:  Spyros A Kalams; Lisa M Rogers; Rita M Smith; Louise Barnett; Katie Crumbo; Shonda Sumner; Naomi Prashad; Kyle Rybczyk; Ginger Milne; Scot E Dowd; Erica Chong; Beverly Winikoff; David M Aronoff
Journal:  Eur J Contracept Reprod Health Care       Date:  2016-09-16       Impact factor: 1.848

2.  Protective role of misoprostol against cisplatin-induced ototoxicity.

Authors:  Murat Doğan; Halil Polat; Mehmet Yaşar; Altan Kaya; Ali Bayram; Fatma Şenel; İbrahim Özcan
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-04-06       Impact factor: 2.503

Review 3.  Mechanisms of action of interferon-beta in multiple sclerosis.

Authors:  B G Arnason; A Dayal; Z X Qu; M A Jensen; K Genç; A T Reder
Journal:  Springer Semin Immunopathol       Date:  1996
  3 in total

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