Literature DB >> 1793038

Lactobacillus casei-induced polyarthritis in Lewis rats: histopathological scoring system for evaluation of anti-rheumatic drugs.

E M O'Byrne1, E D Roberts, A S Rubin, V Blancuzzi, D Wilson, N R Hall, T J Lehman.   

Abstract

A histopathological scoring system which grades drug effects on cellular infiltration, pannus formation, cartilage degradation and bone resorption in L. casei-induced polyarthritis in rats is described. Reference anti-rheumatic and anti-inflammatory agents administered on days 2-60 after induction of arthritis were evaluated for effects on paw swelling weekly and graded histopathologic changes on day 60. This animal model affords a tool to evaluated therapeutic agents on the joint destruction resulting from chronic inflammation.

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Year:  1991        PMID： 1793038     DOI： 10.1007/bf01993291

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  Lactobacillus casei cell wall-induced arthritis in rats: cell wall fragment distribution and persistence in chronic arthritis-susceptible LEW/N and -resistant F344/N rats.

Authors:  T J Lehman; J B Allen; P H Plotz; R L Wilder
Journal:  Arthritis Rheum       Date:  1984-08

Review 2.  Streptococcal cell wall-induced polyarthritis in the rat. Mechanisms for chronicity and regulation of susceptibility.

Authors:  M F van den Broek
Journal:  APMIS       Date:  1989-10       Impact factor: 3.205

3.  Polyarthritis in rats following the systemic injection of Lactobacillus casei cell walls in aqueous suspension.

Authors:  T J Lehman; J B Allen; P H Plotz; R L Wilder
Journal:  Arthritis Rheum       Date:  1983-10

4.  Role of the thymus in streptococcal cell wall-induced arthritis and hepatic granuloma formation. Comparative studies of pathology and cell wall distribution in athymic and euthymic rats.

Authors:  J B Allen; D G Malone; S M Wahl; G B Calandra; R L Wilder
Journal:  J Clin Invest       Date:  1985-09       Impact factor: 14.808

5.  Thymus-dependent and -independent regulation of Ia antigen expression in situ by cells in the synovium of rats with streptococcal cell wall-induced arthritis. Differences in site and intensity of expression in euthymic, athymic, and cyclosporin A-treated LEW and F344 rats.

Authors:  R L Wilder; J B Allen; C Hansen
Journal:  J Clin Invest       Date:  1987-04       Impact factor: 14.808

Review 6.  Mechanisms of bone and cartilage destruction in rheumatoid arthritis: lessons from the streptococcal cell wall arthritis model in LEW/N rats.

Authors:  R L Wilder; R Lafyatis; D E Yocum; J P Case; G K Kumkumian; E F Remmers
Journal:  Clin Exp Rheumatol       Date:  1989 Sep-Oct       Impact factor: 4.473
  6 in total
  2 in total

1.  Pathogenesis of Lactobacillus casei-induced polyarthritis in Lewis rats: 1. Time related changes in histopathological scores and hematology.

Authors:  V Blancuzzi; E D Roberts; D Wilson; L R Fryer; E M O'Byrne; G DiPasquale
Journal:  Agents Actions       Date:  1993

2.  Pathogenesis of Lactobacillus casei-induced polyarthritis in Lewis rats: 2. Time related changes in organ weights and liver enzymes.

Authors:  D Wilson; E M O'Byrne; V Blancuzzi; M Schlosser; C H Borman; G DiPasquale
Journal:  Agents Actions       Date:  1993
  2 in total

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