Literature DB >> 1793031

Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig.

D Vincent1, J Lefort, M Bureau, J Dry, B B Vargaftig.   

Abstract

The interactions between LPS-induced bronchial hyper-reactivity (BHR) and lung inflammation (LI) were investigated. LPS-induced LI was assessed with the augmented alveolo-capillary permeability (ACP) and with the increased migration of neutrophils into the broncho-alveolar lavage fluid. BHR was defined as the increase in the response to a standard dose of serotonin. Mepyramine and the PAF antagonist WEB 2170 blocked LPS-induced increase of ACP, whereas aspirin was inactive. By contrast, neither LPS-induced neutrophil attraction to airways, nor LPS-induced HBR were inhibited by these agents. Our results indicate that LPS-induced edema and BHR are dissociated.

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Year:  1991        PMID： 1793031     DOI： 10.1007/bf01993279

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  4 in total

Review 1.  Inflammation and airway reactivity.

Authors:  J R Snapper; K L Brigham
Journal:  Exp Lung Res       Date:  1984       Impact factor: 2.459

2.  Endotoxin-induced inflammation and injury of the guinea pig respiratory airways cause bronchial hyporeactivity.

Authors:  G Folkerts; P A Henricks; P J Slootweg; F P Nijkamp
Journal:  Am Rev Respir Dis       Date:  1988-06

3.  Role of platelets in aspirin-sensitive bronchoconstriction in the guinea-pig; interactions with salicylic acid.

Authors:  J Lefort; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1978-05       Impact factor: 8.739

4.  Intratracheal E. coli lipopolysaccharide induces platelet-dependent bronchial hyperreactivity.

Authors:  D Vincent; J Lefort; F Chatelet; M F Bureau; J Dry; B B Vargaftig
Journal:  J Appl Physiol (1985)       Date:  1993-03
  4 in total
  2 in total

1.  Involvement of cytokines in lipopolysaccharide-induced facilitation of CGRP release from capsaicin-sensitive nerves in the trachea: studies with interleukin-1beta and tumor necrosis factor-alpha.

Authors:  X Y Hua; P Chen; A Fox; R R Myers
Journal:  J Neurosci       Date:  1996-08-01       Impact factor: 6.167

2.  Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice.

Authors:  Yong-Zheng Wu; Mohammad Abolhassani; Mario Ollero; Fariel Dif; Naonori Uozumi; Micheline Lagranderie; Takao Shimizu; Michel Chignard; Lhousseine Touqui
Journal:  Respir Res       Date:  2010-04-29
  2 in total

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