Literature DB >> 17929980

Concise total synthesis of (-)-spongotine A.

Kenichi Murai1, Maiko Morishita, Ryo Nakatani, Ozora Kubo, Hiromichi Fujioka, Yasuyuki Kita.   

Abstract

The first asymmetric total synthesis of spongotine A is described. The oxidative synthesis of the imidazoline/ketone unit from keto aldehyde and diamine is a key step in this synthesis. The absolute stereochemistry of the asymmetric center of natural spongotine A is revealed as the (S)-configuration.

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Year:  2007        PMID: 17929980     DOI: 10.1021/jo701668s

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

1.  Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.

Authors:  Roya Zoraghi; Liam Worrall; Raymond H See; Wendy Strangman; Wendy L Popplewell; Huansheng Gong; Toufiek Samaai; Richard D Swayze; Sukhbir Kaur; Marija Vuckovic; B Brett Finlay; Robert C Brunham; William R McMaster; Michael T Davies-Coleman; Natalie C Strynadka; Raymond J Andersen; Neil E Reiner
Journal:  J Biol Chem       Date:  2011-10-26       Impact factor: 5.157

2.  Total Synthesis of (+)-Raputindole A: An Iridium-Catalyzed Cyclization Approach.

Authors:  Juliana L L F Regueira; Luiz F Silva; Ronaldo A Pilli
Journal:  Org Lett       Date:  2020-08-05       Impact factor: 6.005

  2 in total

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