| Literature DB >> 17929794 |
Christel A S Bergström1, Carola M Wassvik, Kajsa Johansson, Ina Hubatsch.
Abstract
We determined the intrinsic aqueous solubility of 15 poorly soluble drugs with solubilities ranging from 2.9 nM to 1.1 microM. We then analyzed the data from a physicochemical perspective, using experimentally determined solid-state properties and easily interpretable two-dimensional molecular descriptors, to better understand the factors underlying poor solubility. The analysis shows that poorly soluble drugs that have reached the market are solubility limited by solvation rather than by their solid state.Mesh：
Substances：
Year: 2007 PMID： 17929794 DOI： 10.1021/jm0706416
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446