Role of oxidative stress in mechanisms of premature aging in shift labor workers.

There have been examined 90 practically healthy male-shift-workers 21-58 aged and 21-60 aged (average age 41.4 +/- 1.4 and 48.6 +/- 1.3) who worked for a long period of time in the North on shift at the enterprises of JS "Yamburggasdobycha" at the moment of examination. It was revealed a high content of glycosaminoglycans (GAG) in blood serum (2.20 +/- 0.12 mmol/l), accumulation of LPO products (3.45 +/- 0.18 nmol MDA/ml) against the background of decreased glutationreductase activity (0.38 +/- 0.04 mkmol/l hour). Level of total cholesterol was increased at standard content of HDL (6.1+0.2). It can be concluded that definition of GAG and MDA in blood is one of the significant criteria, reflecting adaptative tension and premature aging of shift-workers.