Literature DB >> 1792947

Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: comparison with TGF-beta 1.

T L Chen1, R L Bates, A Dudley, R G Hammonds, E P Amento.   

Abstract

The biologic effects of recombinant human bone morphogenetic protein-2b (BMP-2b = BMP-4) were studied and compared with transforming growth factor-beta 1 (TGF-beta 1) in fetal rat osteoblast-like (ROB) cells. Similar to the effects of TGF-beta 1, BMP-2b stimulated DNA and collagen synthesis as well as protein accumulation. Unlike TGF-beta 1, which inhibited alkaline phosphatase activity, BMP-2b enhanced enzyme activity eight-to ninefold over the control level. The present study demonstrates direct actions of BMP-2b on bone-associated cells to stimulate osteogenic phenotypes in vitro and provides a cellular mechanism for the induction of bone formation by BMP-2b in vivo.

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Year:  1991        PMID： 1792947     DOI： 10.1002/jbmr.5650061216

Source DB:  PubMed          Journal:  J Bone Miner Res        ISSN： 0884-0431            Impact factor:   6.741


  14 in total

1.  Effect of recombinant human bone morphogenetic protein-2 on the osseointegration of dental implants: a biomechanics study.

Authors:  Nikitas Sykaras; Anthony M Iacopino; Robert G Triplett; Victoria A Marker
Journal:  Clin Oral Investig       Date:  2004-07-29       Impact factor: 3.573

2.  Effects of transforming growth factor-beta1 on the gene expression of decorin, biglycan, and alkaline phosphatase in osteoblast precursor cells and more differentiated osteoblast cells.

Authors:  T Yamada; N Kamiya; D Harada; M Takagi
Journal:  Histochem J       Date:  1999-10

3.  Subtle differences in the mitogenic effects of recombinant human bone morphogenetic proteins -2 to -7 on DNA synthesis on primary bone-forming cells and identification of BMP-2/4 receptor.

Authors:  H Mayer; A M Scutt; T Ankenbauer
Journal:  Calcif Tissue Int       Date:  1996-04       Impact factor: 4.333

4.  Influence of donor age and comorbidities on transduced human adipose-derived stem cell in vitro osteogenic potential.

Authors:  Kevin Collon; Jennifer A Bell; Matthew C Gallo; Stephanie W Chang; Sofia Bougioukli; Osamu Sugiyama; Jade Tassey; Roger Hollis; Nathanael Heckmann; Daniel A Oakes; Donald B Longjohn; Denis Evseenko; Donald B Kohn; Jay R Lieberman
Journal:  Gene Ther       Date:  2022-10-11       Impact factor: 4.184

5.  Modulation of osteogenesis in human mesenchymal stem cells by specific pulsed electromagnetic field stimulation.

Authors:  Ming-Tzu Tsai; Wan-Ju Li; Rocky S Tuan; Walter H Chang
Journal:  J Orthop Res       Date:  2009-09       Impact factor: 3.494

6.  Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

Authors:  E Gazzerro; V Gangji; E Canalis
Journal:  J Clin Invest       Date:  1998-12-15       Impact factor: 14.808

7.  Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype.

Authors:  M Centrella; S Casinghino; J Kim; T Pham; V Rosen; J Wozney; T L McCarthy
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

8.  A new technique for seeding chondrocytes onto solvent-preserved human meniscus using the chemokinetic effect of recombinant human bone morphogenetic protein-2.

Authors:  Hiroaki Minehara; Ken Urabe; Kouji Naruse; Alexander T Mehlhorn; Kentaroo Uchida; Norbert P Südkamp; Moritoshi Itoman
Journal:  Cell Tissue Bank       Date:  2010-06-17       Impact factor: 1.522

9.  Recombinant human bone morphogenetic protein-2 in the treatment of bone fractures.

Authors:  Neil Ghodadra; Kern Singh
Journal:  Biologics       Date:  2008-09

10.  Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.

Authors:  S E Gitelman; M S Kobrin; J Q Ye; A R Lopez; A Lee; R Derynck
Journal:  J Cell Biol       Date:  1994-09       Impact factor: 10.539
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