Jong-Lyel Roh1, Jooryung Huh, Cheolwon Suh. 1. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. rohjl@amc.seoul.kr
Abstract
BACKGROUND: The clinical course of primary salivary gland lymphomas has received little attention. METHODS: We retrospectively assessed 20 patients with previously untreated non-Hodgkin's lymphomas (NHLs) and histologically confirmed as having parenchymal involvement of the salivary glands. The clinical presentation, therapy, and outcomes were compared between the 12 patients with mucosa-associated lymphoid tissue (MALT) lymphomas and the 8 patients with other NHLs. RESULTS: At diagnosis, the 12 patients with MALT lymphoma had a greater mean age and longer duration than did the 8 patients with other NHLs (P < 0.05). Eight of the 12 MALT lymphoma patients had recurrent episodes of salivary gland swelling and 5 had myoepithelial sialadenitis, Sjögren syndrome, or gastric MALT lymphoma; these were not observed in the 8 other NHL patients. Compared with the latter group, the MALT lymphoma group had significantly greater five-year relapse-free (37.5% vs. 91.7%, P < 0.05) and disease-free (35.0% vs. 90.9%, P < 0.05) survival rates. However, two MALT lymphoma patients with high-grade transformation had recurrences beyond the head and neck region. CONCLUSION: Understanding the distinct clinical presentation and course of primary salivary gland lymphomas may help guide the proper diagnosis and management of patients with these tumors. (c) 2007 Wiley-Liss, Inc.
BACKGROUND: The clinical course of primary salivary gland lymphomas has received little attention. METHODS: We retrospectively assessed 20 patients with previously untreated non-Hodgkin's lymphomas (NHLs) and histologically confirmed as having parenchymal involvement of the salivary glands. The clinical presentation, therapy, and outcomes were compared between the 12 patients with mucosa-associated lymphoid tissue (MALT) lymphomas and the 8 patients with other NHLs. RESULTS: At diagnosis, the 12 patients with MALT lymphoma had a greater mean age and longer duration than did the 8 patients with other NHLs (P < 0.05). Eight of the 12 MALT lymphomapatients had recurrent episodes of salivary gland swelling and 5 had myoepithelial sialadenitis, Sjögren syndrome, or gastric MALT lymphoma; these were not observed in the 8 other NHLpatients. Compared with the latter group, the MALT lymphoma group had significantly greater five-year relapse-free (37.5% vs. 91.7%, P < 0.05) and disease-free (35.0% vs. 90.9%, P < 0.05) survival rates. However, two MALT lymphomapatients with high-grade transformation had recurrences beyond the head and neck region. CONCLUSION: Understanding the distinct clinical presentation and course of primary salivary gland lymphomas may help guide the proper diagnosis and management of patients with these tumors. (c) 2007 Wiley-Liss, Inc.
Authors: A Keszler; L I Adler; M S Gandolfo; P A Masquijo Bisio; A C Smith; C F Vollenweider; A M Heidenreich; G de Stefano; M V Kambo; D P Cox; M Narbaitz; H E Lanfranchi Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2012-11-13
Authors: C-P Mejía-Velázquez; M-A Durán-Padilla; E Gómez-Apo; D Quezada-Rivera; L-A Gaitán-Cepeda Journal: Med Oral Patol Oral Cir Bucal Date: 2012-03-01