Literature DB >> 17929098

Closed hyperthermic intraperitoneal chemotherapy with open abdomen: a novel technique to reduce exposure of the surgical team to chemotherapy drugs.

Laurent Benoit1, Nicolas Cheynel, Pablo Ortega-Deballon, Giovanni Di Giacomo, Bruno Chauffert, Patrick Rat.   

Abstract

BACKGROUND: Exposure of the surgical team to toxic drugs during hyperthermic intraperitoneal chemotherapy (HIPEC) remains a matter of great concern. During closed-abdomen HIPEC, operating room staff are not exposed to drugs, but the distribution of the heated liquid within the abdomen is not optimal. With open-abdomen HIPEC, the opposite is true. Although the open-abdomen method is potentially more effective, it has not become a standard procedure because of the risk of exposure of members of the team to drugs.
METHODS: We present a new technique (closed HIPEC with open abdomen) which ensures protection against potentially contaminating exposure to liquids, vapours and aerosols, and allows permanent access to the whole abdominal cavity. Its principle is to extend the abdominal surgical wound upwards with a sort of "glove-box". The cutaneous edges of the laparotomy are stapled to a latex "wall expander". The expander is draped over a special L-section metal frame placed above the abdomen. A transparent cover containing a "hand-access" port, like those used in laparoscopic surgery, is fixed inside the frame.
RESULTS: In 10 patients, this device proved to be hermetic for both liquids and vapours. Intra-abdominal temperature was maintained between 42 and 43 degrees C during most of the procedure. The whole abdominal cavity was accessible to the surgeon, allowing optimal exposure of all peritoneal surfaces.
CONCLUSION: This technique allows optimal HIPEC, while limiting the potential toxic effects for the surgical, medical and paramedical teams.

Entities:  

Mesh:

Year:  2007        PMID: 17929098      PMCID: PMC2887654          DOI: 10.1245/s10434-007-9635-x

Source DB:  PubMed          Journal:  Ann Surg Oncol        ISSN: 1068-9265            Impact factor:   5.344


  26 in total

1.  [Intraperitoneal chemo-hyperthermia with "overflow" open abdomen].

Authors:  P Rat; L Benoit; N Cheynel; L Osmak; P Favoulet; F Peschaud; B Chauffert; J P Favre
Journal:  Ann Chir       Date:  2001-09

2.  Determination of the vaporization of solutions of mutagenic antineoplastic agents at 23 and 37 degrees C using a desiccator technique.

Authors:  T H Connor; M Shults; M P Fraser
Journal:  Mutat Res       Date:  2000-10-10       Impact factor: 2.433

3.  Monitoring for hazardous drugs in the operating room.

Authors:  Thomas H Connor; Peter Van Balen; Paul J M Sessink
Journal:  Ann Surg Oncol       Date:  2003-08       Impact factor: 5.344

4.  Permeability of nitrile rubber, latex, polyurethane, and neoprene gloves to 18 antineoplastic drugs.

Authors:  T H Connor
Journal:  Am J Health Syst Pharm       Date:  1999-12-01       Impact factor: 2.637

5.  Morbidity and mortality analysis of 200 treatments with cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy using the coliseum technique.

Authors:  A D Stephens; R Alderman; D Chang; G D Edwards; J Esquivel; G Sebbag; M A Steves; P H Sugarbaker
Journal:  Ann Surg Oncol       Date:  1999-12       Impact factor: 5.344

6.  Heated intra-operative intraperitoneal oxaliplatin after complete resection of peritoneal carcinomatosis: pharmacokinetics and tissue distribution.

Authors:  D Elias; M Bonnay; J M Puizillou; S Antoun; S Demirdjian; Otmany A El; J P Pignon; L Drouard-Troalen; J F Ouellet; M Ducreux
Journal:  Ann Oncol       Date:  2002-02       Impact factor: 32.976

7.  Safety monitoring of the coliseum technique for heated intraoperative intraperitoneal chemotherapy with mitomycin C.

Authors:  O Anthony Stuart; Arvil D Stephens; Laura Welch; Paul H Sugarbaker
Journal:  Ann Surg Oncol       Date:  2002-03       Impact factor: 5.344

8.  [Treatment of peritoneal carcinomatosis using complete excision and intraperitoneal chemohyperthermia. A phase I-II study defining the best technical procedures].

Authors:  D Elias; S Antoun; B Raynard; J M Puizillout; J C Sabourin; M Ducreux; P Lasser
Journal:  Chirurgie       Date:  1999-09

9.  Investigations on safety of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) with Mitomycin C.

Authors:  K Schmid; M I Boettcher; J O W Pelz; T Meyer; G Korinth; J Angerer; H Drexler
Journal:  Eur J Surg Oncol       Date:  2006-06-19       Impact factor: 4.424

10.  Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer.

Authors:  Vic J Verwaal; Serge van Ruth; Eeclo de Bree; Gooike W van Sloothen; Harm van Tinteren; Henk Boot; Frans A N Zoetmulder
Journal:  J Clin Oncol       Date:  2003-10-15       Impact factor: 44.544

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  15 in total

Review 1.  Peritoneal Metastases from Gastrointestinal Cancer.

Authors:  Paul H Sugarbaker
Journal:  Curr Oncol Rep       Date:  2018-06-08       Impact factor: 5.075

2.  Prevention and Treatment of Peritoneal Metastases: a Comprehensive Review.

Authors:  Paul H Sugarbaker
Journal:  Indian J Surg Oncol       Date:  2019-01-03

3.  Different sequential approaches of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treating ovarian cancer with malignant ascites.

Authors:  Mingchen Ba; Hui Long; Xiangliang Zhang; Yunqiang Tang; Yinbing Wu; Feihong Yu; Shuai Wang; Shuzhong Cui
Journal:  J Cancer Res Clin Oncol       Date:  2014-05-22       Impact factor: 4.553

4.  Chemotherapy with laparoscope-assisted continuous circulatory hyperthermic intraperitoneal perfusion for malignant ascites.

Authors:  Ming-Chen Ba; Shu-Zhong Cui; Sheng-Qu Lin; Yun-Qiang Tang; Yin-Bing Wu; Bin Wang; Xiang-Liang Zhang
Journal:  World J Gastroenterol       Date:  2010-04-21       Impact factor: 5.742

Review 5.  Hyperthermic intraperitoneal chemotherapy in prevention of gastric cancer metachronous peritoneal metastases: a systematic review.

Authors:  Mikhail Yu Reutovich; Olga V Krasko; Oleg G Sukonko
Journal:  J Gastrointest Oncol       Date:  2021-04

6.  Cytoreductive Surgery and Intraperitoneal Chemotherapy in Advanced Serous Epithelial Ovarian Cancer: A 14-Year French Retrospective Single-Center Study of 124 Patients.

Authors:  Brice Paquette; Elsa Kalbacher; Frédéric Mercier; Zaher Lakkis; Alexandre Doussot; Célia Turco; Edda Caputo; Sébastien Pili-Floury; Bernard Royer; Laura Mansi; Delphine Delroeux; Martin Demarchi; Xavier Pivot; Bruno Chauffert; Elise Clement; Bruno Heyd
Journal:  Ann Surg Oncol       Date:  2022-01-07       Impact factor: 5.344

Review 7.  Surgical technology and pharmacology of hyperthermic perioperative chemotherapy.

Authors:  Paul H Sugarbaker; Kurt Van der Speeten
Journal:  J Gastrointest Oncol       Date:  2016-02

8.  Multivariate comparison of B-ultrasound guided and laparoscopic continuous circulatory hyperthermic intraperitoneal perfusion chemotherapy for malignant ascites.

Authors:  Ming-Chen Ba; Hui Long; Shu-Zhong Cui; Yun-Qiang Tang; Yin-Bing Wu; Xiang-Liang Zhang; Hong-Sheng Tang; Sai-Xi Bai
Journal:  Surg Endosc       Date:  2013-02-08       Impact factor: 4.584

9.  Laparoscopic mucin removal in patients with pseudomyxoma peritonei.

Authors:  Yasushi Kotani; Mitsuru Shiota; Masahiko Umemoto; Takako Tobiume; Eiji Koike; Masao Shimaoka; Yohko Takahashi; Kazumi Kanemura; Ayako Ishizu; Hiroshi Hoshiai
Journal:  JSLS       Date:  2009 Apr-Jun       Impact factor: 2.172

10.  Evaluation of oxaliplatin exposure of healthcare workers during heated intraperitoneal perioperative chemotherapy (HIPEC).

Authors:  Antoine F Villa; Souleiman El Balkhi; Radia Aboura; Herve Sageot; Helene Hasni-Pichard; Marc Pocard; Dominique Elias; Nathalie Joly; Didier Payen; François Blot; Joel Poupon; Robert Garnier
Journal:  Ind Health       Date:  2014-10-17       Impact factor: 2.179

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