Literature DB >> 17928698

Identification and determination of alpha-dicarbonyl compounds formed in the degradation of sugars.

Teruyuki Usui1, Satoshi Yanagisawa, Mio Ohguchi, Miku Yoshino, Risa Kawabata, Junko Kishimoto, Yumi Arai, Kaoru Aida, Hirohito Watanabe, Fumitaka Hayase.   

Abstract

The alpha-dicarbonyl compounds formed in the degradation of glucose and fructose were analyzed by HPLC using 2,3-diaminonaphthalene as derivatizing reagent, and identified as glucosone (GLUCO), 3-deoxyglucosone (3DG), 3-deoxyxylosone (3DX), tetrosone (TSO), triosone (TRIO), 3-deoxytetrosone (3DT), glyoxal (GO), and methylglyoxal (MGO). The results suggest that alpha-dicarbonyl compounds were formed from glucose via non-oxidative 3-deoxyglucosone formation and oxidative glucosone formation in glucose degradation. In addition, TRIO, GO, and MGO were also formed from glyceraldehyde as intermediate. The alpha-dicarbonyl compounds might be formed from glucose via these pathways in diabetes.

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Year:  2007        PMID： 17928698     DOI： 10.1271/bbb.70229

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

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Journal:  Chem Res Toxicol       Date:  2015-06-17       Impact factor: 3.739

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4.  Identification of Kynoxazine, a Novel Fluorescent Product of the Reaction between 3-Hydroxykynurenine and Erythrulose in the Human Lens, and Its Role in Protein Modification.

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Journal:  J Biol Chem       Date:  2016-03-03       Impact factor: 5.157

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Authors:  Eun Sil Kim; Varoujan Yaylayan
Journal:  Curr Res Food Sci       Date:  2021-04-21

6.  Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney.

Authors:  Masanori Katakura; Michio Hashimoto; Yoko Tanabe; Osamu Shido
Journal:  Med Gas Res       Date:  2012-07-09

7.  Association between Advanced Glycation End Products and Impaired Fasting Glucose: Results from the SALIA Study.

Authors:  Tom Teichert; Anne Hellwig; Annette Peßler; Michael Hellwig; Mohammad Vossoughi; Dorothea Sugiri; Andrea Vierkötter; Thomas Schulte; Juliane Freund; Michael Roden; Barbara Hoffmann; Tamara Schikowski; Christian Luckhaus; Ursula Krämer; Thomas Henle; Christian Herder
Journal:  PLoS One       Date:  2015-05-27       Impact factor: 3.240
  7 in total

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