Literature DB >> 17928547

No potassium, no acid: K+ channels and gastric acid secretion.

Dirk Heitzmann1, Richard Warth.   

Abstract

The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.

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Year:  2007        PMID： 17928547     DOI： 10.1152/physiol.00016.2007

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  25 in total

1.  Physiology of the Vc-NhaP paralogous group of cation-proton antiporters in Vibrio cholerae.

Authors:  Muntahi Mourin; Carla B Schubiger; Craig T Resch; Claudia C Häse; Pavel Dibrov
Journal:  Mol Cell Biochem       Date:  2017-01-13       Impact factor: 3.396

2.  KCNQ1 is the luminal K+ recycling channel during stimulation of gastric acid secretion.

Authors:  Penghong Song; Stephanie Groos; Brigitte Riederer; Zhe Feng; Anja Krabbenhöft; Adam Smolka; Ursula Seidler
Journal:  J Physiol       Date:  2009-06-02       Impact factor: 5.182

3.  KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice.

Authors:  Qin Pan; Jun Ma; Qinshu Zhou; Jun Li; Yongqing Tang; Yi Liu; Yiqing Yang; Junjie Xiao; Luying Peng; Pengjuan Li; Dandan Liang; Hong Zhang; Yi-Han Chen
Journal:  Mol Biol Rep       Date:  2009-03-21       Impact factor: 2.316

4.  Acid secretion-associated translocation of KCNJ15 in gastric parietal cells.

Authors:  Wenjun He; Wensheng Liu; Catherine S Chew; Susan S Baker; Robert D Baker; John G Forte; Lixin Zhu
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2011-06-30       Impact factor: 4.052

Review 5.  Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.

Authors:  Francisco V Sepúlveda; L Pablo Cid; Jacques Teulon; María Isabel Niemeyer
Journal:  Physiol Rev       Date:  2015-01       Impact factor: 37.312

6.  Acid suppression by proton pump inhibitors enhances aquaporin-4 and KCNQ1 expression in gastric fundic parietal cells in mouse.

Authors:  Juntaro Matsuzaki; Hidekazu Suzuki; Yuriko Minegishi; Etsuko Sugai; Hitoshi Tsugawa; Masato Yasui; Toshifumi Hibi
Journal:  Dig Dis Sci       Date:  2010-05-01       Impact factor: 3.199

7.  AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.

Authors:  Rodrigo Alzamora; Fan Gong; Christine Rondanino; Jeffrey K Lee; Christy Smolak; Núria M Pastor-Soler; Kenneth R Hallows
Journal:  Am J Physiol Renal Physiol       Date:  2010-09-22

8.  Role of indigenous lactobacilli in gastrin-mediated acid production in the mouse stomach.

Authors:  Hidenori Takahashi; Yasuhiro Nakano; Takashi Matsuoka; Nobue Kumaki; Yukio Asami; Yasuhiro Koga
Journal:  Appl Environ Microbiol       Date:  2011-07-29       Impact factor: 4.792

9.  Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium.

Authors:  Raphael Rapetti-Mauss; Fiona O'Mahony; Francisco V Sepulveda; Valerie Urbach; Brian J Harvey
Journal:  J Physiol       Date:  2013-03-25       Impact factor: 5.182

Review 10.  Pancreatic pathophysiology in cystic fibrosis.

Authors:  Katherine N Gibson-Corley; David K Meyerholz; John F Engelhardt
Journal:  J Pathol       Date:  2015-10-01       Impact factor: 7.996
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