| Literature DB >> 17927986 |
Georgina P Colo1, Roberto R Rosato, Steven Grant, Mónica A Costas.
Abstract
The nuclear receptor coactivator RAC3 plays important roles in many biological processes and tumorigenesis. We found that RAC3 is over-expressed in human chronic myeloid leukemia cells K562, which are normally resistant to TRAIL-induced apoptosis. RAC3 down-regulation by siRNA rendered these cells sensitive to TRAIL-induced cell death. In addition to the up-regulation of TRAIL receptors, the process involves Bid, caspases and PARP activation, loss of mitochondrial membrane potential, and release of AIF, cytochrome c and Smac/DIABLO to the cytoplasm. We conclude that RAC3 is required for TRAIL resistance and that this anti-apoptotic function is independent of its role in hormone receptor signaling.Entities:
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Year: 2007 PMID： 17927986 DOI： 10.1016/j.febslet.2007.09.052
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124