A Wallin1, S Ekberg, K Lind, V Milos, A-K Granérus, G Granerus. 1. Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Goteborg University, Mölndal, Sweden. anders.wallin@neuro.gu.se
Abstract
OBJECTIVES: The aim of the study was to visualize cortical function in Parkinson's patients with various degrees of cognitive impairment. MATERIALS AND METHODS: Thirty-seven patients with Parkinson's disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using (99m)TC-HMPAO-SPECT. RESULTS: Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment (n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment (n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia (n = 10). CONCLUSIONS: The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.
OBJECTIVES: The aim of the study was to visualize cortical function in Parkinson'spatients with various degrees of cognitive impairment. MATERIALS AND METHODS: Thirty-seven patients with Parkinson's disease and three with Parkinson plus syndromes underwent cognitive assessment and rCBF using (99m)TC-HMPAO-SPECT. RESULTS: Almost no regional reductions in cerebral blood flow were seen in patients without cognitive impairment (n = 16). Limited, mainly posterior, blood flow reductions were seen in patients with mild cognitive impairment (n = 14), whereas the reductions were extensive and bilaterally symmetric, involving both anterior and posterior brain regions in patients with dementia (n = 10). CONCLUSIONS: The findings suggest a widespread cortical, mainly posterior type of dysfunction and a relationship between the degree of cognitive impairment and the magnitude of the dysfunction.
Authors: Noemí Fabelo; Virginia Martín; Gabriel Santpere; Raquel Marín; Laia Torrent; Isidre Ferrer; Mario Díaz Journal: Mol Med Date: 2011-06-22 Impact factor: 6.354