Literature DB >> 17927652

Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms.

Gabriella Di Rosa1, Sarina Attinà, Maria Spanò, Giulia Ingegneri, Domenica L Sgrò, Giuseppina Pustorino, Maria Bonsignore, Vincenzo Trapani-Lombardo, Gaetano Tortorella.   

Abstract

MTHFR gene variants C677T and A1298C seem to be related to an increased risk of migraine. Folates' metabolism could play a role in the pathophysiology of migraine. We supplemented 16 children with migraine, hyperhomocysteinemia, and MTHFR polymorphisms with folic acid and obtained a resolution/reduction of migraine attacks. Although the mechanism leading to these effects has been not made clear, we believe that the use of folic acid needs further investigations in migraineurs with hyperhomocysteinemia and MTHFR variants. A randomized, double-blind, placebo controlled crossover trial is needed to support these findings.

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Year:  2007        PMID： 17927652     DOI： 10.1111/j.1526-4610.2007.00932.x

Source DB:  PubMed          Journal:  Headache        ISSN： 0017-8748            Impact factor:   5.887


  12 in total

1.  Association of endothelial nitric oxide synthase gene polymorphisms (894G/T, -786T/C, G10T) and clinical findings in patients with migraine.

Authors:  Recep Eröz; Anzel Bahadir; Suber Dikici; Sener Tasdemir
Journal:  Neuromolecular Med       Date:  2014-05-22       Impact factor: 3.843

2.  Oral supplementation of folic acid for two months reduces total serum homocysteine levels in hyperhomocysteinemic Greek children.

Authors:  D Papandreou; P Malindretos; M Arvanitidou; A Makedou; I Rousso
Journal:  Hippokratia       Date:  2010-04       Impact factor: 0.471

3.  Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis.

Authors:  Zainab Samaan; Daria Gaysina; Sarah Cohen-Woods; Nick Craddock; Lisa Jones; Ania Korszun; Mike Owen; Andrew Mente; Peter McGuffin; Anne Farmer
Journal:  BMC Neurol       Date:  2011-06-02       Impact factor: 2.474

4.  Association between serum levels of homocysteine with characteristics of migraine attacks in migraine with aura.

Authors:  Omid Sadeghi; Zahra Maghsoudi; Gholamreza Askari; Fariborz Khorvash; Awat Feizi
Journal:  J Res Med Sci       Date:  2014-11       Impact factor: 1.852

Review 5.  Vitamin supplementation as possible prophylactic treatment against migraine with aura and menstrual migraine.

Authors:  Munvar Miya Shaik; Siew Hua Gan
Journal:  Biomed Res Int       Date:  2015-02-28       Impact factor: 3.411

6.  Dietary Intake of Thiamine in Migraine Patients and Healthy Subjects: a Case-Control Study.

Authors:  Hossein Faraji; Zamzam Paknahad; Ahmad Chitsaz
Journal:  Clin Nutr Res       Date:  2018-01-31

7.  Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and headache in children: a retrospective study from a tertiary level outpatient service.

Authors:  A Orsini; I Sammartino; A Valetto; V Bertini; P Marchese; A Bonuccelli; D G Peroni
Journal:  Ital J Pediatr       Date:  2018-08-31       Impact factor: 2.638

8.  Rs4846049 Polymorphism at the 3'-UTR of MTHFR Gene: Association with Susceptibility to Childhood Acute Lymphoblastic Leukemia.

Authors:  Xiaolei Li; Shunguo Zhang; Feng Yu
Journal:  Biomed Res Int       Date:  2019-10-13       Impact factor: 3.411

9.  Assessment of pyridoxine and folate intake in migraine patients.

Authors:  Omid Sadeghi; Zahra Maghsoudi; Fariborz Khorvash; Reza Ghiasvand; Gholamreza Askari
Journal:  Adv Biomed Res       Date:  2016-03-16

10.  The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients.

Authors:  Saras Menon; Bushra Nasir; Nesli Avgan; Sussan Ghassabian; Christopher Oliver; Rodney Lea; Maree Smith; Lyn Griffiths
Journal:  J Headache Pain       Date:  2016-06-23       Impact factor: 7.277
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