Spontaneous intestinal perforation.

So much is unknown about SIP-its etiology, pathophysiology, best treatment modality, and outcome. Yet the incidence of SIP is increasing as more VLBW infants are surviving and since SIP has been identified as a separate disease from NEC. Because many cases present with an insidious onset, it is imperative that practitioners review all x-rays with SIP in mind. Although SIP is a relatively rare occurrence in the NICU, its potential to increase morbidity and mortality in premature infants warrants further research to improve outcomes.