[Guideline for prophylaxis and treatment of NSAID-associated gastric ulcerations].

Both Helicobacter pylori (H. pylori) infection and non-steroidal anti-inflammatory drug (NSAID) administration independently and significantly increase the risk of peptic ulceration and ulcer bleeding as its complication. Because of increasing ratio of the senior generation in Japan, the relative role of NSAID including low-dose aspirin as an anti-platelet therapy, will be more important in the pathogenesis of peptic ulcerations. In order to prevent peptic ulcerations, one of the major adverse events of NSAID, a series of selective COX-2 inhibitors has been developed and some of them have been widely used clinically. However, long-term use of a COX-2 inhibitor may be associated with higher risk of cardiovascular events and strokes. Herein, we focus on prophylaxis and treatment of NSAID-associated gastric ulcerations.