Ajeet Singh1. 1. The Geelong Clinic, Geelong, Victoria. ajeetsingh@dodo.com.au
Abstract
BACKGROUND: Matching patients to effective tolerable medications can take months of trial and error. Genetic factors can strongly influence drug response. One of the potential clinical applications of the Human Genome Project is prediction of medication response--pharmacogenomics. OBJECTIVE: This article reviews the emerging field of pharmacogenomics and its clinical potential using the example of antidepressant and anticoagulant medication prescribing. DISCUSSION: Growing evidence suggests genomic profiling for common variants in cytochrome P450 enzymes and transport systems involving serotonin, noradrenaline and the blood-brain barrier could inform antidepressant prescribing. Similarly, genetic testing for variants in cytochrome CYP2C9 and vitamin K epoxide reductase could inform decisions about prescribing warfarin. Large clinical trials to determine the clinical utility of this approach are required before pharmacogenomics enters routine clinical practice.
BACKGROUND: Matching patients to effective tolerable medications can take months of trial and error. Genetic factors can strongly influence drug response. One of the potential clinical applications of the Human Genome Project is prediction of medication response--pharmacogenomics. OBJECTIVE: This article reviews the emerging field of pharmacogenomics and its clinical potential using the example of antidepressant and anticoagulant medication prescribing. DISCUSSION: Growing evidence suggests genomic profiling for common variants in cytochrome P450 enzymes and transport systems involving serotonin, noradrenaline and the blood-brain barrier could inform antidepressant prescribing. Similarly, genetic testing for variants in cytochrome CYP2C9 and vitamin K epoxide reductase could inform decisions about prescribing warfarin. Large clinical trials to determine the clinical utility of this approach are required before pharmacogenomics enters routine clinical practice.
Authors: Seetal Dodd; Gin S Malhi; John Tiller; Isaac Schweitzer; Ian Hickie; Jon Paul Khoo; Darryl L Bassett; Bill Lyndon; Philip B Mitchell; Gordon Parker; Paul B Fitzgerald; Marc Udina; Ajeet Singh; Steven Moylan; Francesco Giorlando; Carolyn Doughty; Christopher G Davey; Michael Theodoros; Michael Berk Journal: Aust N Z J Psychiatry Date: 2011-09 Impact factor: 5.744
Authors: Xin Gu; Tao Huang; Ding Xu; Liujian Duan; Yang Jiao; Jian Kang; S Lilly Zheng; Jianfeng Xu; Jielin Sun; Jun Qi Journal: Biochem Res Int Date: 2013-08-01