Literature DB >> 17924694

A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-crispine A.

Steven M Allin1, Sean N Gaskell, Joannah M R Towler, Philip C Bulman Page, Basu Saha, Michael J McKenzie, William P Martin.   

Abstract

We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.

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Year:  2007        PMID: 17924694     DOI: 10.1021/jo071235x

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  2 in total

1.  Design, synthesis and cytotoxicity of the antitumor agent 1-azabicycles for chemoresistant glioblastoma cells.

Authors:  Mona Oliveira; Lourenço Luis Botelho de Santana; José Claudio Serafim; Airam Oliveira Santos; Michelle Pereira Quintino; José Tiago Menezes Correia; Fabiano Damasceno; José Ricardo Sabino; Thiago Rubens Cardim Pires; Paulo Lucas Cerqueira Coelho; Giselle Pinto de Faria Lopes; Henning Ulrich; Silvia Lima Costa; Silvio Cunha
Journal:  Invest New Drugs       Date:  2019-12-14       Impact factor: 3.850

2.  Synthesis of crispine A analogues via an intramolecular Schmidt reaction.

Authors:  Ajoy Kapat; Ponminor Senthil Kumar; Sundarababu Baskaran
Journal:  Beilstein J Org Chem       Date:  2007-12-19       Impact factor: 2.883

  2 in total

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