OBJECTIVE: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease. DESIGN: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain. PARTICIPANTS: Eight patients with probable Alzheimer disease and 8 healthy volunteers. RESULTS: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes. CONCLUSION: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.
OBJECTIVE: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease. DESIGN: Functional connectivity magnetic resonance imaging was used to investigate coherence in the magnetic resonance signal between the hippocampus and all other regions of the brain. PARTICIPANTS: Eight patients with probable Alzheimer disease and 8 healthy volunteers. RESULTS: Control subjects showed hippocampal functional connectivity with diffuse cortical, subcortical, and cerebellar sites, while patients demonstrated markedly reduced functional connectivity, including an absence of connectivity with the frontal lobes. CONCLUSION: These findings suggest a functional disconnection between the hippocampus and other brain regions in patients with Alzheimer disease.
Authors: Susanne Erk; Andreas Meyer-Lindenberg; Carola Opitz von Boberfeld; Christine Esslinger; Knut Schnell; Peter Kirsch; Manuel Mattheisen; Thomas W Mühleisen; Sven Cichon; Stephanie H Witt; Marcella Rietschel; Markus M Nöthen; Henrik Walter Journal: J Neurosci Date: 2011-12-07 Impact factor: 6.167
Authors: S Duke Han; Konstantinos Arfanakis; Debra A Fleischman; Sue E Leurgans; Elizabeth R Tuminello; Emily C Edmonds; David A Bennett Journal: J Int Neuropsychol Soc Date: 2011-10-18 Impact factor: 2.892
Authors: Elisa Canu; Donald G McLaren; Michele E Fitzgerald; Barbara B Bendlin; Giada Zoccatelli; Franco Alessandrini; Francesca B Pizzini; Giuseppe K Ricciardi; Alberto Beltramello; Sterling C Johnson; Giovanni B Frisoni Journal: J Alzheimers Dis Date: 2011 Impact factor: 4.472
Authors: Ahmed A Moustafa; Szabolcs Keri; Mohammad M Herzallah; Catherine E Myers; Mark A Gluck Journal: Brain Cogn Date: 2010-08-21 Impact factor: 2.310
Authors: Willem Huijbers; Aaron P Schultz; Patrizia Vannini; Donald G McLaren; Sarah E Wigman; Andrew M Ward; Trey Hedden; Reisa A Sperling Journal: J Cogn Neurosci Date: 2013-02-05 Impact factor: 3.225