Literature DB >> 17923496

In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin.

G Sóczó1, G Kardos, I Varga, B Kelentey, R Gesztelyi, L Majoros.   

Abstract

Paradoxical growth was noted in RPMI 1640 and antibiotic medium 3 in the case of 14 and 1 of 15 Candida tropicalis strains, respectively, at a caspofungin concentration of 12.5 microg/ml using minimum fungicidal concentration tests. Time-kill assays showed that against isolates killed at lower concentrations, caspofungin at a concentration of 12.5 microg/ml was only fungistatic.

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Year:  2007        PMID： 17923496      PMCID： PMC2168010          DOI： 10.1128/AAC.00880-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.

Authors:  David A Stevens; Masayuki Ichinomiya; Yukako Koshi; Hiroyuki Horiuchi
Journal:  Antimicrob Agents Chemother       Date:  2006-09       Impact factor: 5.191

2.  Influence of test conditions on antifungal time-kill curve results: proposal for standardized methods.

Authors:  M E Klepser; E J Ernst; R E Lewis; M E Ernst; M A Pfaller
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

3.  Caspofungin susceptibility testing of Candida inconspicua: correlation of different methods with the minimal fungicidal concentration.

Authors:  L Majoros; G Kardos; B Szabó; M Sipiczki
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

4.  Micafungin activity against Candida bloodstream isolates: effect of growth medium and susceptibility testing method.

Authors:  Manjunath P Pai; Ariel L Jones; Casey K Mullen
Journal:  Diagn Microbiol Infect Dis       Date:  2007-01-19       Impact factor: 2.803

5.  Assessment of the paradoxical effect of caspofungin in therapy of candidiasis.

Authors:  Karl V Clemons; Marife Espiritu; Rachana Parmar; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

6.  Paradoxical effect of Echinocandins across Candida species in vitro: evidence for echinocandin-specific and candida species-related differences.

Authors:  Georgios Chamilos; Russell E Lewis; Nathaniel Albert; Dimitrios P Kontoyiannis
Journal:  Antimicrob Agents Chemother       Date:  2007-04-16       Impact factor: 5.191

7.  Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations.

Authors:  David A Stevens; Marife Espiritu; Rachana Parmar
Journal:  Antimicrob Agents Chemother       Date:  2004-09       Impact factor: 5.191

8.  Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis.

Authors:  Peter G Pappas; Coleman M F Rotstein; Robert F Betts; Marcio Nucci; Deepak Talwar; Jan J De Waele; Jose A Vazquez; Bertrand F Dupont; David L Horn; Luis Ostrosky-Zeichner; Annette C Reboli; Byungse Suh; Raghunadharao Digumarti; Chunzhang Wu; Laura L Kovanda; Leah J Arnold; Donald N Buell
Journal:  Clin Infect Dis       Date:  2007-08-29       Impact factor: 9.079

9.  Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity.

Authors:  Nathan P Wiederhold; Dimitrios P Kontoyiannis; Jingduan Chi; Randall A Prince; Vincent H Tam; Russell E Lewis
Journal:  J Infect Dis       Date:  2004-09-10       Impact factor: 5.226

10.  Influences of methodological variables on susceptibility testing of caspofungin against Candida species and Aspergillus fumigatus.

Authors:  C Bartizal; F C Odds
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191
  10 in total
  5 in total

1.  In vivo studies with a Candida tropicalis isolate exhibiting paradoxical growth in vitro in the presence of high concentration of caspofungin.

Authors:  Sedigh Bayegan; Laszlo Majoros; Gabor Kardos; Adam Kemény-Beke; Cecilia Miszti; Renato Kovacs; Rudolf Gesztelyi
Journal:  J Microbiol       Date:  2010-05-01       Impact factor: 3.422

Review 2.  Antifungal Susceptibility Testing: Current Approaches.

Authors:  Elizabeth L Berkow; Shawn R Lockhart; Luis Ostrosky-Zeichner
Journal:  Clin Microbiol Rev       Date:  2020-04-29       Impact factor: 26.132

3.  Changes in cell wall synthesis and ultrastructure during paradoxical growth effect of caspofungin on four different Candida species.

Authors:  Fernando C Bizerra; Analy S A Melo; Eduardo Katchburian; Edna Freymüller; Anita H Straus; Hélio K Takahashi; Arnaldo L Colombo
Journal:  Antimicrob Agents Chemother       Date:  2010-11-08       Impact factor: 5.191

4.  Paradoxical growth of Candida albicans in the presence of caspofungin is associated with multiple cell wall rearrangements and decreased virulence.

Authors:  Cristina Rueda; Manuel Cuenca-Estrella; Oscar Zaragoza
Journal:  Antimicrob Agents Chemother       Date:  2013-12-02       Impact factor: 5.191

Review 5.  An Update on Candida tropicalis Based on Basic and Clinical Approaches.

Authors:  Diana L Zuza-Alves; Walicyranison P Silva-Rocha; Guilherme M Chaves
Journal:  Front Microbiol       Date:  2017-10-13       Impact factor: 5.640
  5 in total

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